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Tbio
SUSD4
Sushi domain-containing protein 4

Protein Summary
Description
Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343846
  • ENSP00000344219
  • ENSG00000143502
  • ENST00000344029
  • ENSP00000339926
  • ENST00000366878
  • ENSP00000355843

Symbol
  • PRO222
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
PubMedID
0.72
cell type or tissue
0.64
gene perturbation
0.63
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.16   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (52)
1 – 10 of 52
DHPS
Tbio
Family: Enzyme
Novelty: 0.00776893
p_int: 0.999994801
p_ni: 0.000005199
Data Source: BioPlex
HSD17B8
Tbio
Family: Enzyme
Novelty: 0.00915958
p_int: 0.999992259
p_ni: 0.000005136
p_wrong: 0.000002606
Data Source: BioPlex
ITGA8
Tbio
Novelty: 0.0220023
p_int: 0.999557171
p_ni: 0.000442678
p_wrong: 1.5e-7
Data Source: BioPlex
ITGA7
Tbio
Novelty: 0.01243073
p_int: 0.999257032
p_ni: 0.000742968
Data Source: BioPlex
FUT11
Tbio
Family: Enzyme
Novelty: 0.16098097
p_int: 0.996511578
p_ni: 0.003488421
p_wrong: 1e-9
Data Source: BioPlex
CCDC85C
Tdark
Novelty: 0.30053883
p_int: 0.991679541
p_ni: 0.008320459
Data Source: BioPlex
PLXNA2
Tbio
Novelty: 0.01765957
p_int: 0.988352233
p_ni: 0.011647767
Data Source: BioPlex
PCOLCE2
Tbio
Family: Enzyme
Novelty: 0.13084379
p_int: 0.986319526
p_ni: 0.013443649
p_wrong: 0.000236825
Data Source: BioPlex
LRP5
Tbio
Novelty: 0.00089807
p_int: 0.98324608
p_ni: 0.016753799
p_wrong: 1.21e-7
Score: 0.151
Data Source: BioPlex,STRINGDB
ARSK
Tbio
Family: Enzyme
Novelty: 0.11486213
p_int: 0.978180898
p_ni: 0.021819085
p_wrong: 1.6e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  6.16

PubMed score by year
PubTator Score  4.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer