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Tbio
LYPLAL1
Lysophospholipase-like protein 1

Protein Summary
Description
Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366927
  • ENSP00000355894
  • ENSG00000143353
  • ENST00000366928
  • ENSP00000355895

Symbol
  • Q96AV0
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.77
interacting protein
0.66
transcription factor
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.53   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.53   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (81)
1 – 10 of 81
TM6SF2
Tbio
Novelty: 0.00965899
Score: 0.842
Data Source: STRINGDB
SAMM50
Tbio
Novelty: 0.00553631
Score: 0.757
Data Source: STRINGDB
PNPLA3
Tbio
Family: Enzyme
Novelty: 0.00180327
Score: 0.745
Data Source: STRINGDB
PPP1R3B
Tbio
Family: Enzyme
Novelty: 0.0244434
Score: 0.736
Data Source: STRINGDB
ABHD17A
Tbio
Family: Enzyme
Novelty: 0.26144756
Score: 0.714
Data Source: STRINGDB
NCAN
Tbio
Novelty: 0.00401824
Score: 0.705
Data Source: STRINGDB
GCKR
Tchem
Family: Enzyme
Novelty: 0.00798717
Score: 0.685
Data Source: STRINGDB
CILP2
Tbio
Novelty: 0.07992715
Score: 0.68
Data Source: STRINGDB
TFAP2B
Tbio
Family: TF
Novelty: 0.01383202
Score: 0.663
Data Source: STRINGDB
MSRA
Tbio
Family: Enzyme
Novelty: 0.00595154
Score: 0.634
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.53

PubMed score by year
PubTator Score  15.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer