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Tbio
LYPLAL1
Lysophospholipase-like protein 1

Protein Summary
Description
Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366927
  • ENSP00000355894
  • ENSG00000143353
  • ENST00000366928
  • ENSP00000355895

Symbol
  • Q96AV0
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.77
interacting protein
0.66
transcription factor
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.83   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.83   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
TM6SF2
Tbio
Novelty:  0.00965899
Score:  0.842
Data Source:  STRINGDB
SAMM50
Tbio
Novelty:  0.00553631
Score:  0.757
Data Source:  STRINGDB
PNPLA3
Tbio
Family:  Enzyme
Novelty:  0.00180327
Score:  0.745
Data Source:  STRINGDB
PPP1R3B
Tbio
Family:  Enzyme
Novelty:  0.0244434
Score:  0.736
Data Source:  STRINGDB
ABHD17A
Tbio
Family:  Enzyme
Novelty:  0.26144756
Score:  0.714
Data Source:  STRINGDB
NCAN
Tbio
Novelty:  0.00401824
Score:  0.705
Data Source:  STRINGDB
GCKR
Tchem
Family:  Enzyme
Novelty:  0.00798717
Score:  0.685
Data Source:  STRINGDB
CILP2
Tbio
Novelty:  0.07992715
Score:  0.68
Data Source:  STRINGDB
TFAP2B
Tbio
Family:  TF
Novelty:  0.01383202
Score:  0.663
Data Source:  STRINGDB
MSRA
Tbio
Family:  Enzyme
Novelty:  0.00595154
Score:  0.634
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
8
35
43
99.5
hip circumference
2
31
36
99.4
waist-hip ratio
3
32
32
99.4
BMI-adjusted hip circumference
2
26
29
99.3
waist circumference
2
17
17
94.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
43
99.5
hip circumference
36
99.4
waist-hip ratio
32
99.4
BMI-adjusted hip circumference
29
99.3
waist circumference
17
94.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysophospholipase like 1
VGNC:6911
457743
Macaque
lysophospholipase like 1
707313
Mouse
MGI:2385115
226791
Rat
RGD:1311195
289357
Dog
lysophospholipase like 1
VGNC:42892
100855625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysophospholipase like 1
Macaque
lysophospholipase like 1
Mouse
Rat
Dog
lysophospholipase like 1
Publication Statistics
PubMed Score 23.83
PubMed score by year
PubTator Score 15.78
PubTator score by year
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Related Publications
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PMID
Year
Title