Tbio KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 2

Protein Summary

Description

RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.

Uniprot Accession IDs

• Q5VWX1
• A8K7M8
• Q8N4I4
• Q8TCZ4

Gene Name

• KHDRBS2

Ensembl ID

• ENST00000281156
• ENSP00000281156
• ENSG00000112232

Symbol

• SLM1
• SLM1
• SLM-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.85
trait	0.75
cell line	0.63
molecular function	0.6
tissue sample	0.58

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Kh Domain-containing, Rna-binding, Signal Transduction-associated Protein 2

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Kh Domain-containing, Rna-binding, Signal Transduction-associated Protein 2

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Kh Domain-containing, Rna-binding, Signal Transduction-associated Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.63   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.63   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0