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Tbio
C1QL3
Complement C1q-like protein 3

Protein Summary
Description
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298943
  • ENSP00000298943
  • ENSG00000165985
  • ENST00000619991
  • ENSP00000480149

Symbol
  • CTRP13
  • C1ql
  • K100
  • CTRP13
  • C1QTNF13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.59
cell type or tissue
0.52
microRNA
0.44
tissue sample
0.44
chemical
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.07   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.07   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
80.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
80.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C1q like 3
VGNC:14317
738723
Macaque
complement C1q like 3
100429967
Mouse
MGI:2387350
227580
Rat
RGD:1591795
680404
Cow
complement C1q like 3
VGNC:50059
614045
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C1q like 3
Macaque
complement C1q like 3
Mouse
Rat
Cow
complement C1q like 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5VWW1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (30)
1 – 10 of 30
YPEL4
Tdark
Novelty:  0.64726628
Score:  0.694
Data Source:  STRINGDB
NEUROD6
Tbio
Family:  TF
Novelty:  0.02073347
Score:  0.676
Data Source:  STRINGDB
YPEL1
Tbio
Novelty:  0.17068379
Score:  0.667
Data Source:  STRINGDB
SLIT1
Tbio
Novelty:  0.01255624
Score:  0.657
Data Source:  STRINGDB
ADGRB3
Tbio
Family:  GPCR
Novelty:  0.03769616
Score:  0.599
Data Source:  STRINGDB
PVALB
Tbio
Novelty:  0.00024439
Score:  0.577
Data Source:  STRINGDB
FNDC5
Tbio
Novelty:  0.0015827
Score:  0.568
Data Source:  STRINGDB
C15orf62
Tdark
Novelty:  28
Score:  0.535
Data Source:  STRINGDB
SNPH
Tbio
Novelty:  0.02572001
Score:  0.532
Data Source:  STRINGDB
TMEM163
Tbio
Novelty:  0.04613489
Score:  0.515
Data Source:  STRINGDB
Publication Statistics
PubMed Score  22.07

PubMed score by year
PubTator Score  17.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer