Tbio TENT5C Terminal nucleotidyltransferase 5C

Protein Summary

Description

Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death. (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.

Uniprot Accession IDs

• Q5VWP2
• A3KMG2
• Q8NE25
• Q9NXK0

Gene Name

• TENT5C

Ensembl ID

• ENST00000369448
• ENSP00000358458
• ENSG00000183508

Symbol

• FAM46C
• FAM46C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
transcription factor perturbation	0.74
small molecule perturbation	0.7
transcription factor binding site profile	0.67
histone modification site profile	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 96   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.55   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0