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Tbio
TENT5C
Terminal nucleotidyltransferase 5C

Protein Summary
Description
Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death. (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369448
  • ENSP00000358458
  • ENSG00000183508

Symbol
  • FAM46C
  • FAM46C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
transcription factor perturbation
0.74
small molecule perturbation
0.7
transcription factor binding site profile
0.67
histone modification site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.84   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.84   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
DIS3
Tbio
Family:  Enzyme
Novelty:  0.00961238
Score:  0.731
Data Source:  STRINGDB
CGAS
Tchem
Family:  Enzyme
Novelty:  0.00239778
Score:  0.642
Data Source:  STRINGDB
TENT4B
Tbio
Family:  Enzyme
Novelty:  0.06266066
Score:  0.609
Data Source:  STRINGDB
MB21D2
Tdark
Novelty:  0.48908631
Score:  0.581
Data Source:  STRINGDB
ITPRIPL2
Tdark
Novelty:  1.92099276
Score:  0.581
Data Source:  STRINGDB
SP140
Tbio
Family:  TF; Epigenetic
Novelty:  0.04734307
Score:  0.58
Data Source:  STRINGDB
LY6E
Tbio
Novelty:  0.00758512
Score:  0.569
Data Source:  STRINGDB
MCOLN2
Tchem
Family:  IC
Novelty:  0.05195244
Score:  0.56
Data Source:  STRINGDB
Q9NQG6
Tbio
Novelty:  0.04096049
Score:  0.551
Data Source:  STRINGDB
L0R8F8
Tbio
Novelty:  0.04096049
Score:  0.551
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
6
9
99
reticulocyte count
7
4
11
97.7
mean platelet volume
3
3
3
97.1
monocyte count
2
2
2
89.3
platelet count
1
1
1
82.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
9
99
reticulocyte count
11
97.7
mean platelet volume
3
97.1
monocyte count
2
89.3
platelet count
1
82.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
family with sequence similarity 46 member C
714457
Mouse
MGI:1921895
74645
Rat
RGD:1359446
310721
Dog
terminal nucleotidyltransferase 5C
VGNC:40683
483142
Horse
terminal nucleotidyltransferase 5C
VGNC:17875
100059755
Species
Name
OMA
EggNOG
Inparanoid
Macaque
family with sequence similarity 46 member C
Mouse
Rat
Dog
terminal nucleotidyltransferase 5C
Horse
terminal nucleotidyltransferase 5C
Publication Statistics
PubMed Score 22.84
PubMed score by year
PubTator Score 7.15
PubTator score by year
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Related Publications
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PMID
Year
Title