TENT5C
Terminal nucleotidyltransferase 5C
Protein Summary
Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endoplasmic reticulum-targeted protein and may be involved in induction of cell death. (Microbial infection) Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
- ENST00000369448
- ENSP00000358458
- ENSG00000183508
- FAM46C
- FAM46C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
transcription factor perturbation | 0.74 | ||
small molecule perturbation | 0.7 | ||
transcription factor binding site profile | 0.67 | ||
histone modification site profile | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.84 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 96 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.84 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 96 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (56)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 6 | 9 | 99 | |||||
reticulocyte count | 7 | 4 | 11 | 97.7 | |||||
mean platelet volume | 3 | 3 | 3 | 97.1 | |||||
monocyte count | 2 | 2 | 2 | 89.3 | |||||
platelet count | 1 | 1 | 1 | 82.5 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 9 | 99 | |||||
reticulocyte count | 11 | 97.7 | |||||
mean platelet volume | 3 | 97.1 | |||||
monocyte count | 2 | 89.3 | |||||
platelet count | 1 | 82.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | family with sequence similarity 46 member C | 714457 | ||||||
Mouse | MGI:1921895 | 74645 | ||||||
Rat | RGD:1359446 | 310721 | ||||||
Dog | terminal nucleotidyltransferase 5C | VGNC:40683 | 483142 | |||||
Horse | terminal nucleotidyltransferase 5C | VGNC:17875 | 100059755 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | family with sequence similarity 46 member C | |||||
Mouse | ||||||
Rat | ||||||
Dog | terminal nucleotidyltransferase 5C | |||||
Horse | terminal nucleotidyltransferase 5C | |||||
Publication Statistics
PubMed Score 22.84
PubMed score by year
PubTator Score 7.15
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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