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Tbio
IL23R
Interleukin-23 receptor

Protein Summary
Description
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.92
trait
0.86
phenotype
0.8
disease
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.12   (req: < 5)
Gene RIFs: 274   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.12   (req: >= 5)
Gene RIFs: 274   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
0
2.5
99.8
6
5
0
1.7
99.4
3
3
0
1.2
96.6
2
1
0
2.3
95.2
2
1
0
1.6
92
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.5
99.8
0
1.7
99.4
0
1.2
96.6
0
2.3
95.2
0
1.6
92
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-23 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-12 family signaling
Interleukin-23 signaling
Interleukin-4 and Interleukin-13 signaling
Gene Ontology Terms (31)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (223)
1 – 10 of 223
IL23A
Tclin
Novelty: 0.00440193
Score: 0.996
Data Source: Reactome,STRINGDB
IL12B
Tclin
Novelty: 0.0157417
Score: 0.991
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.987
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.98
Data Source: Reactome,STRINGDB
IL12RB1
Tbio
Novelty: 0.00398741
Score: 0.98
Data Source: Reactome,STRINGDB
STAT4
Tbio
Family: TF
Novelty: 0.00251747
Score: 0.966
Data Source: Reactome,STRINGDB
TYK2
Tclin
Family: Kinase
Novelty: 0.00237955
Score: 0.963
Data Source: Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.949
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.945
Data Source: STRINGDB
STAT6
Tchem
Family: TF
Novelty: 0.00096732
Score: 0.937
Data Source: STRINGDB
Publication Statistics
PubMed Score  222.12

PubMed score by year
PubTator Score  364.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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