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Tbio
TAF3
Transcription initiation factor TFIID subunit 3

Protein Summary
Description
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344293
  • ENSP00000340271
  • ENSG00000165632

Symbol
  • TAF140
  • TAFII140
  • TAFII-140
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.88
histone modification site profile
0.87
protein domain
0.85
virus perturbation
0.85
biological process
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.71   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.71   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (192)
TAF7L
Tbio
Novelty:  0.08132691
p_int:  0.999999996
p_ni:  1e-9
p_wrong:  3e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999996
p_ni:  4e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
SPATA25
Tbio
Novelty:  0.80142563
p_int:  0.999999996
p_ni:  4e-9
Data Source:  BioPlex
TAF8
Tbio
Novelty:  0.01056638
p_int:  0.999999995
p_ni:  5e-9
Score:  0.988
Data Source:  BioPlex,STRINGDB
TAF6
Tbio
Novelty:  0.04357176
Score:  0.999
Data Source:  STRINGDB
TAF10
Tbio
Novelty:  0.0276004
Score:  0.999
Data Source:  STRINGDB
TAF5
Tbio
Novelty:  0.05443551
Score:  0.998
Data Source:  STRINGDB
TAF1
Tchem
Family:  Kinase
Novelty:  0.00555929
Score:  0.998
Data Source:  STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.998
Data Source:  STRINGDB
TAF11
Tchem
Novelty:  0.10299251
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
Generic Transcription Pathway
HIV Infection
HIV Life Cycle
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
1
2
2
95.9
lymphocyte count
2
2
2
88
eosinophil count
3
2
3
83
eosinophil percentage of leukocytes
1
1
1
73.9
calcium measurement
1
2
2
70.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
2
95.9
lymphocyte count
2
88
eosinophil count
3
83
eosinophil percentage of leukocytes
1
73.9
calcium measurement
2
70.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 3
VGNC:5802
450295
Mouse
MGI:2388097
209361
Dog
TATA-box binding protein associated factor 3
VGNC:47081
487135
Cow
TATA-box binding protein associated factor 3
VGNC:35574
506674
Pig
TATA-box binding protein associated factor 3
100620508
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 3
Mouse
Dog
TATA-box binding protein associated factor 3
Cow
TATA-box binding protein associated factor 3
Pig
TATA-box binding protein associated factor 3
Publication Statistics
PubMed Score 17.71
PubMed score by year
PubTator Score 14.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title