Tbio YOD1 Ubiquitin thioesterase OTU1

Protein Summary

Description

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622). Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q5VVQ6
• B2RNX3
• Q5VVQ5
• Q6ZRS6
• Q86T63
• Q9P1L8

Gene Name

• YOD1

Ensembl ID

• ENST00000315927
• ENSP00000326813
• ENSG00000180667
• ENST00000367084
• ENSP00000356051

Symbol

• DUBA8
• HIN7
• OTUD2
• DUBA8
• OTUD2
• PRO0907

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.93
cellular component	0.73
transcription factor binding site profile	0.68
histone modification site profile	0.63
tissue sample	0.6

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Ubiquitin Thioesterase Otu1

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Ubiquitin Thioesterase Otu1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.55   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 144   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.55   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0