MYSM1
Histone H2A deubiquitinase MYSM1
Protein Summary
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
- ENST00000472487
- ENSP00000418734
- ENSG00000162601
- ENST00000622766
- ENSP00000478391
- KIAA1915
- 2ADUB
- BMFS4
- 2A-DUB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.88 | ||
protein domain | 0.85 | ||
cell type or tissue | 0.71 | ||
microRNA | 0.68 | ||
biological process | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.73 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 250 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.73 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 250 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0