Tbio ARHGEF16 Rho guanine nucleotide exchange factor 16

Protein Summary

Description

Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q5VV41
• Q86TF0
• Q99434

Gene Name

• ARHGEF16

Ensembl ID

• ENST00000378371
• ENSP00000367622
• ENSG00000130762
• ENST00000378373
• ENSP00000367624
• ENST00000378378
• ENSP00000367629

Symbol

• EPHEXIN4
• NBR
• NBR
• GEF16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.68
small molecule perturbation	0.63
histone modification site profile	0.6
tissue sample	0.59
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 777.11   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 777.11   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0