Tbio SDHAF4 Succinate dehydrogenase assembly factor 4, mitochondrial

Protein Summary

Description

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity).

Uniprot Accession IDs

• Q5VUM1
• E1P532
• SDH assembly factor 4

Gene Name

• SDHAF4

Ensembl ID

• ENST00000370474
• ENSP00000359505
• ENSG00000154079

Symbol

• C6orf57
• Sdh8
• C6orf57

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
cell type or tissue	0.75
tissue	0.7
tissue sample	0.59
virus perturbation	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.85   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.85   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0