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Tdark
EFCAB2
Dynein regulatory complex protein 8

Protein Summary
Description
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. The gene encodes a protein that contains two EF-hand calcium-binding domains although its function has yet to be determined. Alternatively spliced transcripts have been observed. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366522
  • ENSP00000355479
  • ENSG00000203666
  • ENST00000366523
  • ENSP00000355480
  • ENST00000447569
  • ENSP00000408661

Symbol
  • DRC8
  • DRC8
  • CFAP200
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
microRNA
0.97
cellular component
0.84
transcription factor perturbation
0.68
small molecule perturbation
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.999996816
p_wrong:  0.000003184
Score:  0.228
Data Source:  BioPlex,STRINGDB
PSKH1
Tbio
Family:  Kinase
Novelty:  0.20577182
Score:  0.776
Data Source:  STRINGDB
PGBD5
Tdark
Novelty:  0.15960609
Score:  0.77
Data Source:  STRINGDB
IQCD
Tbio
Novelty:  0.21789956
Score:  0.762
Data Source:  STRINGDB
IQCA1
Tdark
Novelty:  0.33986781
Score:  0.747
Data Source:  STRINGDB
IQCG
Tbio
Novelty:  0.19968917
Score:  0.745
Data Source:  STRINGDB
GIN1
Tbio
Family:  Enzyme
Novelty:  0.0247804
Score:  0.694
Data Source:  STRINGDB
GALNT2
Tchem
Family:  Enzyme
Novelty:  0.02458542
Score:  0.681
Data Source:  STRINGDB
PPEF2
Tbio
Family:  Enzyme
Novelty:  0.18717195
Score:  0.677
Data Source:  STRINGDB
DESI2
Tbio
Family:  Enzyme
Novelty:  0.026329
Score:  0.666
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.8
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
14.2
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EF-hand calcium binding domain 2
VGNC:1233
469735
Mouse
MGI:1915476
68226
Cow
EF-hand calcium binding domain 2
VGNC:28343
615715
Pig
EF-hand calcium binding domain 2
100515403
Anole lizard
EF-hand calcium binding domain 2
100554898
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EF-hand calcium binding domain 2
Mouse
Cow
EF-hand calcium binding domain 2
Pig
EF-hand calcium binding domain 2
Anole lizard
EF-hand calcium binding domain 2
Publication Statistics
PubMed Score 2.76
PubMed score by year
PubTator Score 1.38
PubTator score by year
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Related Publications
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PMID
Year
Title