Tdark EFCAB2 Dynein regulatory complex protein 8

Protein Summary

Description

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. The gene encodes a protein that contains two EF-hand calcium-binding domains although its function has yet to be determined. Alternatively spliced transcripts have been observed. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q5VUJ9
• B4DZE9
• Q59G23
• Q9BS36

Gene Name

• EFCAB2

Ensembl ID

• ENST00000366522
• ENSP00000355479
• ENSG00000203666
• ENST00000366523
• ENSP00000355480
• ENST00000447569
• ENSP00000408661

Symbol

• DRC8
• DRC8
• CFAP200

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.98
microRNA	0.97
cellular component	0.84
transcription factor perturbation	0.68
small molecule perturbation	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.33   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.33   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0