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Tbio
AGBL4
Cytosolic carboxypeptidase 6

Protein Summary
Description
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371839
  • ENSP00000360905
  • ENSG00000186094

Symbol
  • CCP6
  • CCP6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.75
phenotype
0.69
histone modification site profile
0.67
molecular function
0.67
virus perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.44   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.44   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
7
6
17
92.8
smoking status measurement
1
1
1
75.6
unipolar depression
1
1
0
1
69
waist-hip ratio
2
1
2
68.3
visceral adipose tissue measurement
1
1
1
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
17
92.8
smoking status measurement
1
75.6
unipolar depression
0
1
69
waist-hip ratio
2
68.3
visceral adipose tissue measurement
1
68
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATP/GTP binding protein like 4
711073
Mouse
MGI:1918244
78933
Horse
ATP/GTP binding protein like 4 [Source:HGNC Symbol;Acc:HGNC:25892]
Opossum
ATP/GTP binding protein like 4
100619105
Zebrafish
ZDB-GENE-081104-437
550450
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATP/GTP binding protein like 4
Mouse
Horse
ATP/GTP binding protein like 4 [Source:HGNC Symbol;Acc:HGNC:25892]
Opossum
ATP/GTP binding protein like 4
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5VU57-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (27)
1 – 10 of 27
TTLL4
Tbio
Family:  Enzyme
Novelty:  0.14127442
Score:  0.839
Data Source:  STRINGDB
TTLL6
Tdark
Family:  Enzyme
Novelty:  0.15224272
Score:  0.798
Data Source:  STRINGDB
TTLL1
Tdark
Family:  Enzyme
Novelty:  0.09244899
Score:  0.754
Data Source:  STRINGDB
TTLL5
Tbio
Family:  Enzyme
Novelty:  0.10212919
Score:  0.703
Data Source:  STRINGDB
CPXM2
Tbio
Family:  Enzyme
Novelty:  0.09967229
Score:  0.675
Data Source:  STRINGDB
LHPP
Tbio
Family:  Enzyme
Novelty:  0.0356879
Score:  0.647
Data Source:  STRINGDB
TTLL11
Tdark
Family:  Enzyme
Novelty:  0.72069227
Score:  0.604
Data Source:  STRINGDB
TTLL9
Tdark
Family:  Enzyme
Novelty:  0.17881456
Score:  0.603
Data Source:  STRINGDB
TTL
Tchem
Family:  Enzyme
Novelty:  0.03494724
Score:  0.598
Data Source:  STRINGDB
TTLL7
Tbio
Family:  Enzyme
Novelty:  0.14162171
Score:  0.547
Data Source:  STRINGDB
Publication Statistics
PubMed Score  15.44

PubMed score by year
PubTator Score  5.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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