HHAT
Protein-cysteine N-palmitoyltransferase HHAT
Protein Summary
Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP. 'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002]
- ENST00000261458
- ENSP00000261458
- ENSG00000054392
- ENST00000367010
- ENSP00000355977
- ENST00000413764
- ENSP00000416845
- ENST00000537898
- ENSP00000442625
- ENST00000541565
- ENSP00000444995
- ENST00000545154
- ENSP00000438468
- ENST00000625523
- ENSP00000486634
- ENSG00000280680
- ENST00000625820
- ENSP00000486054
- ENST00000626327
- ENSP00000487414
- ENST00000627903
- ENSP00000487400
- ENST00000628693
- ENSP00000486611
- ENST00000629360
- ENSP00000486128
- MART2
- SKI1
- Skn
- SKI1
- MART2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.86 | ||
virus perturbation | 0.76 | ||
PubMedID | 0.71 | ||
transcription factor binding site profile | 0.71 | ||
transcription factor | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 263.07 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 263.07 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0