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Tbio
HHAT
Protein-cysteine N-palmitoyltransferase HHAT

Protein Summary
Description
Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP. 'Skinny hedgehog' (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of 'hedgehog' (see MIM 600725).[supplied by OMIM, Jul 2002]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261458
  • ENSP00000261458
  • ENSG00000054392
  • ENST00000367010
  • ENSP00000355977
  • ENST00000413764
  • ENSP00000416845
  • ENST00000537898
  • ENSP00000442625
  • ENST00000541565
  • ENSP00000444995
  • ENST00000545154
  • ENSP00000438468
  • ENST00000625523
  • ENSP00000486634
  • ENSG00000280680
  • ENST00000625820
  • ENSP00000486054
  • ENST00000626327
  • ENSP00000487414
  • ENST00000627903
  • ENSP00000487400
  • ENST00000628693
  • ENSP00000486611
  • ENST00000629360
  • ENSP00000486128

Symbol
  • MART2
  • SKI1
  • Skn
  • SKI1
  • MART2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
virus perturbation
0.76
PubMedID
0.71
transcription factor binding site profile
0.71
transcription factor
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.45   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.45   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.6
50.7
1
1
0
2.6
50.7
triglyceride measurement
1
1
1
10
triglyceride measurement
1
1
1
10
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.6
50.7
0
2.6
50.7
triglyceride measurement
1
10
triglyceride measurement
1
10
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hedgehog acyltransferase
VGNC:11448
469670
Mouse
MGI:2444681
226861
Rat
RGD:1311746
289344
Dog
hedgehog acyltransferase
VGNC:41679
480017
Horse
hedgehog acyltransferase
VGNC:18772
100055589
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hedgehog acyltransferase
Mouse
Rat
Dog
hedgehog acyltransferase
Horse
hedgehog acyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5VTY9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
HHAT G278V abrogates palmitoylation of Hh-Np
Reactome
Hedgehog ligand biogenesis
Reactome
Hh mutants abrogate ligand secretion
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
HHAT G278V abrogates palmitoylation of Hh-Np
Hedgehog ligand biogenesis
Hh mutants abrogate ligand secretion
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (52)
1 – 10 of 52
SHH
Tchem
Novelty: 0.00028347
Score: 0.975
Data Source: Reactome,STRINGDB
IHH
Tbio
Novelty: 0.00174847
Score: 0.969
Data Source: STRINGDB
DHH
Tbio
Novelty: 0.00329784
Score: 0.968
Data Source: STRINGDB
AASDH
Tbio
Family: Enzyme
Novelty: 0.17181708
Score: 0.774
Data Source: STRINGDB
PROZ
Tbio
Family: Enzyme
Novelty: 0.05629679
Score: 0.754
Data Source: STRINGDB
SERPINA10
Tbio
Family: Enzyme
Novelty: 0.01229147
Score: 0.753
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.726
Data Source: STRINGDB
MLANA
Tbio
Novelty: 0.00070835
Score: 0.711
Data Source: STRINGDB
DISP1
Tbio
Novelty: 0.04770784
Score: 0.692
Data Source: STRINGDB
BCL2L10
Tchem
Novelty: 0.01389535
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  200.45

PubMed score by year
PubTator Score  105.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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