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Tbio
RNF20
E3 ubiquitin-protein ligase BRE1A

Protein Summary
Description
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin lig ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
hub protein
0.96
ligand (protein) perturbation
0.96
molecular function
0.94
biological process
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.39   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.39   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (184)
WAC
Tbio
Novelty:  0.02189388
p_int:  0.999999979
p_ni:  1.7e-8
p_wrong:  4e-9
Score:  0.975
Data Source:  BioPlex,STRINGDB
IL36A
Tbio
Novelty:  0.03569425
p_int:  0.999998021
p_ni:  0.000001976
p_wrong:  3e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999991612
p_ni:  0.000008388
Data Source:  BioPlex
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.999955814
p_ni:  0.000044185
p_wrong:  1e-9
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999913381
p_ni:  0.000086619
Data Source:  BioPlex
COG6
Tbio
Novelty:  0.02874093
p_int:  0.99970468
p_ni:  0.00029532
Score:  0.202
Data Source:  BioPlex,STRINGDB
RBM12B
Tdark
Novelty:  0.96079205
p_int:  0.99969103
p_ni:  0.00030897
Data Source:  BioPlex
G0S2
Tbio
Novelty:  0.02273959
p_int:  0.999620364
p_ni:  0.000379636
Data Source:  BioPlex
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.99853266
p_ni:  0.00146734
Score:  0.25
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.998352792
p_ni:  0.001647208
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
3
3
9.9
95.9
mean corpuscular hemoglobin concentration
1
1
1
40.7
self reported educational attainment
1
1
1
33.1
mathematical ability
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
9.9
95.9
mean corpuscular hemoglobin concentration
1
40.7
self reported educational attainment
1
33.1
mathematical ability
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 20
VGNC:4851
464625
Macaque
ring finger protein 20
713614
Mouse
MGI:1925927
109331
Rat
RGD:1311936
313216
Dog
ring finger protein 20
VGNC:45653
474788
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 20
Macaque
ring finger protein 20
Mouse
Rat
Dog
ring finger protein 20
Publication Statistics
PubMed Score 92.39
PubMed score by year
PubTator Score 46.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title