Tdark CFAP126 Protein Flattop

Protein Summary

Description

Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear.

Uniprot Accession IDs

• Q5VTH2

Gene Name

• CFAP126

Ensembl ID

• ENST00000367974
• ENSP00000356951
• ENSG00000188931

Symbol

• C1orf192
• FLTP
• Fltp
• Flattop
• C1orf192

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.61
virus perturbation	0.59
tissue sample	0.43
cell line	0.39
cell type or tissue	0.37

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.6   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.6   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0