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Tbio
RNF220
E3 ubiquitin-protein ligase RNF220

Protein Summary
Description
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355387
  • ENSP00000347548
  • ENSG00000187147
  • ENST00000361799
  • ENSP00000354872
  • ENST00000372247
  • ENSP00000361321

Symbol
  • C1orf164
  • C1orf164
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
transcription factor perturbation
0.74
transcription factor
0.68
transcription factor binding site profile
0.65
PubMedID
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.01   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (308)
1 – 10 of 308
ZC4H2
Tbio
Novelty:  0.04969464
p_int:  0.9999939
p_ni:  5.39e-7
p_wrong:  0.000005561
Score:  0.654
Data Source:  BioPlex,STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
p_int:  0.999811258
p_ni:  0.000017048
p_wrong:  0.000171694
Score:  0.942
Data Source:  BioPlex,STRINGDB
WDR5B
Tdark
Novelty:  1.29746249
p_int:  0.999510588
p_ni:  0.000488795
p_wrong:  6.16e-7
Score:  0.203
Data Source:  BioPlex,STRINGDB
UBE2W
Tbio
Novelty:  0.07255713
p_int:  0.999001456
p_ni:  0.00098426
p_wrong:  0.000014284
Score:  0.902
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.997244031
p_ni:  0.001060066
p_wrong:  0.001695903
Data Source:  BioPlex
DDX54
Tbio
Family:  Enzyme
Novelty:  0.12769464
p_int:  0.995731338
p_ni:  0.000405472
p_wrong:  0.00386319
Data Source:  BioPlex
RPL37
Tbio
Novelty:  0.03935854
p_int:  0.994086059
p_ni:  0.000362698
p_wrong:  0.005551243
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.993189543
p_ni:  0.000925803
p_wrong:  0.005884654
Data Source:  BioPlex
CLEC3A
Tdark
Novelty:  0.21498836
p_int:  0.988792951
p_ni:  0.000728534
p_wrong:  0.010478515
Score:  0.179
Data Source:  BioPlex,STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.937
Data Source:  STRINGDB
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
4
2
4
67.5
red blood cell distribution width
1
1
1
53.7
heart rate response to exercise
2
1
3
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate response to recovery post exercise
4
67.5
red blood cell distribution width
1
53.7
heart rate response to exercise
3
52.4
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 220
VGNC:11018
456515
Macaque
ring finger protein 220
100428142
Mouse
MGI:1913993
66743
Dog
ring finger protein 220
612846
Horse
ring finger protein 220
VGNC:22472
100052861
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 220
Macaque
ring finger protein 220
Mouse
Dog
ring finger protein 220
Horse
ring finger protein 220
Publication Statistics
PubMed Score 9.01
PubMed score by year
PubTator Score 1.52
PubTator score by year