Tbio LRRC38 Leucine-rich repeat-containing protein 38

Protein Summary

Description

Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium.

Uniprot Accession IDs

• Q5VT99
• Q96B32

Gene Name

• LRRC38

Ensembl ID

• ENST00000376085
• ENSP00000365253
• ENSG00000162494

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.76
protein domain	0.58
cell type or tissue	0.54
microRNA	0.54
cell line	0.47

Protein Classes

DTO Classes

Protein / Ion Channel / Leucine-rich Repeat-containing Protein 38

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.73   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.73   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0