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Tbio
MARC1
Mitochondrial amidoxime-reducing component 1

Protein Summary
Description
As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.92
tissue sample
0.66
cellular component
0.65
cell type or tissue
0.64
histone modification site profile
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.4   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.4   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
2
3
96
low density lipoprotein cholesterol measurement
6
4
13
95.3
total cholesterol measurement
5
5
10
93.5
vitamin D measurement
3
2
3
91.3
high density lipoprotein cholesterol measurement
4
1
5
75.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
96
low density lipoprotein cholesterol measurement
13
95.3
total cholesterol measurement
10
93.5
vitamin D measurement
3
91.3
high density lipoprotein cholesterol measurement
5
75.3
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913362
66112
Rat
RGD:1592219
690745
Dog
mitochondrial amidoxime reducing component 1
VGNC:43013
488601
Platypus
mitochondrial amidoxime reducing component 1
100080974
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mitochondrial amidoxime reducing component 1
Platypus
mitochondrial amidoxime reducing component 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5VT66-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Protein-Protein Interactions (43)
1 – 10 of 43
LRRTM1
Tbio
Novelty: 0.0409182
p_int: 0.997921847
p_ni: 0.002078153
Data Source: BioPlex
SRPRB
Tbio
Novelty: 0.04735362
p_int: 0.958489435
p_ni: 0.041510565
Data Source: BioPlex
TMEM30A
Tbio
Novelty: 0.05115559
p_int: 0.92533595
p_ni: 0.07466405
Score: 0.153
Data Source: BioPlex,STRINGDB
ZNRF4
Tbio
Novelty: 0.16505328
p_int: 0.904934169
p_ni: 0.09506583
p_wrong: 1e-9
Data Source: BioPlex
SPINT2
Tbio
Family: Enzyme
Novelty: 0.0046602
p_int: 0.889855502
p_ni: 0.110144498
Data Source: BioPlex
GDPD5
Tbio
Family: Enzyme
Novelty: 0.05871733
p_int: 0.850043852
p_ni: 0.149956147
p_wrong: 1e-9
Data Source: BioPlex
PCDHGA5
Tdark
Novelty: 2.13631603
p_int: 0.757911604
p_ni: 0.242088396
Data Source: BioPlex
CYB5B
Tbio
Novelty: 0.09395308
Score: 0.959
Data Source: Reactome,STRINGDB
CYB5R3
Tbio
Family: Enzyme
Novelty: 0.00774258
Score: 0.946
Data Source: Reactome,STRINGDB
MARC2
Tbio
Novelty: 0.05210077
Score: 0.906
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  20.40

PubMed score by year
PubTator Score  7.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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