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Tchem
CDC42BPA
Serine/threonine-protein kinase MRCK alpha

Protein Summary
Description
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334218
  • ENSP00000335341
  • ENSG00000143776
  • ENST00000366767
  • ENSP00000355729
  • ENST00000366769
  • ENSP00000355731

Symbol
  • KIAA0451
  • MRCK
  • MRCKA
  • PK428
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.96
transcription factor perturbation
0.96
virus perturbation
0.94
metabolite
0.82


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.68   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.68   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
85.9
myeloid white cell count
2
2
2
82.5
optic disc area measurement
2
2
3
76.6
smoking status measurement
1
1
1
70.6
leukocyte count
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
85.9
myeloid white cell count
2
82.5
optic disc area measurement
3
76.6
smoking status measurement
1
70.6
leukocyte count
1
39.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
CDC42 binding protein kinase alpha
697811
Mouse
MGI:2441841
226751
Rat
RGD:621406
114116
Dog
CDC42 binding protein kinase alpha
VGNC:38997
480107
Horse
CDC42 binding protein kinase alpha
VGNC:16296
100054548
Species
Name
OMA
EggNOG
Inparanoid
Macaque
CDC42 binding protein kinase alpha
Mouse
Rat
Dog
CDC42 binding protein kinase alpha
Horse
CDC42 binding protein kinase alpha
Protein-Protein Interactions (80)
1 – 10 of 80
LURAP1L
Tdark
Novelty: 2.32630524
p_int: 0.999999926
p_ni: 7.4e-8
Score: 0.282
Data Source: BioPlex,STRINGDB
FAM167A
Tbio
Novelty: 0.05232679
p_int: 0.999999502
p_ni: 4.98e-7
Score: 0.226
Data Source: BioPlex,STRINGDB
CDKN2D
Tbio
Family: Enzyme
Novelty: 0.01445471
p_int: 0.999947205
p_ni: 0.000052795
Data Source: BioPlex
KCTD17
Tbio
Novelty: 0.12105733
p_int: 0.999885558
p_ni: 0.000114436
p_wrong: 7e-9
Data Source: BioPlex
INKA2
Tdark
Novelty: 0.57898295
p_int: 0.999691477
p_ni: 0.000308523
Score: 0.309
Data Source: BioPlex,STRINGDB
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.999663401
p_ni: 0.000336599
Score: 0.171
Data Source: BioPlex,STRINGDB
LATS1
Tbio
Family: Kinase
Novelty: 0.00369058
p_int: 0.989021993
p_ni: 0.010978007
Data Source: BioPlex
RPL28
Tbio
Novelty: 0.03136035
p_int: 0.986071488
p_ni: 0.013928512
Data Source: BioPlex
RPL23A
Tbio
Novelty: 0.02951947
p_int: 0.927902411
p_ni: 0.072097582
p_wrong: 7e-9
Data Source: BioPlex
FCGR1A
Tchem
Novelty: 0.00073204
p_int: 0.849254386
p_ni: 0.150745614
Score: 0.195
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  35.68

PubMed score by year
PubTator Score  26.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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