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Tbio
CEP350
Centrosome-associated protein 350

Protein Summary
Description
Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript va ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367607
  • ENSP00000356579
  • ENSG00000135837

Symbol
  • CAP350
  • KIAA0480
  • GM133
  • CAP350
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
histone modification site profile
0.84
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.78
cell type or tissue
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.47   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.47   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
44.7
mean corpuscular volume
1
2
2
42
smoking initiation
1
1
1
26.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
44.7
mean corpuscular volume
2
42
smoking initiation
1
26.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 350
VGNC:493
457555
Macaque
centrosomal protein 350
716537
Mouse
MGI:1921331
74081
Rat
RGD:621162
246304
Dog
centrosomal protein 350
VGNC:39127
480028
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 350
Macaque
centrosomal protein 350
Mouse
Rat
Dog
centrosomal protein 350
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (113)
1 – 10 of 113
FGFR1OP
Tbio
Novelty: 0.09922864
p_int: 0.999999991
p_ni: 7e-9
p_wrong: 2e-9
Score: 0.985
Data Source: BioPlex,STRINGDB
CEP19
Tbio
Novelty: 0.20749222
p_int: 0.999999989
p_ni: 1.1e-8
Score: 0.594
Data Source: BioPlex,STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
p_int: 0.999999693
p_ni: 3.03e-7
p_wrong: 3e-9
Score: 0.586
Data Source: BioPlex,STRINGDB
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.999756366
p_ni: 0.000243634
Score: 0.171
Data Source: BioPlex,STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
p_int: 0.999085267
p_ni: 0.000914733
Score: 0.326
Data Source: BioPlex,STRINGDB
DISC1
Tbio
Novelty: 0.00183442
p_int: 0.992842083
p_ni: 0.007157917
Data Source: BioPlex
PIP
Tbio
Novelty: 0.00208509
p_int: 0.990754132
p_ni: 0.00193946
p_wrong: 0.007306409
Data Source: BioPlex
RNF10
Tbio
Novelty: 0.09086567
p_int: 0.953856973
p_ni: 0.046143027
Data Source: BioPlex
XRN1
Tbio
Family: Enzyme
Novelty: 0.00409381
Score: 0.854
Data Source: STRINGDB
BDP1
Tbio
Novelty: 0.00497963
Score: 0.815
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.47

PubMed score by year
PubTator Score  5.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer