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Tbio
ABHD17B
Alpha/beta hydrolase domain-containing protein 17B

Protein Summary
Description
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333421
  • ENSP00000330222
  • ENSG00000107362
  • ENST00000377041
  • ENSP00000366240

Symbol
  • C9orf77
  • FAM108B1
  • CGI-67
  • C9orf77
  • FAM108B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
histone modification site profile
0.79
transcription factor binding site profile
0.72
transcription factor
0.7
small molecule perturbation
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.31   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.31   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 17B
VGNC:13848
464524
Macaque
abhydrolase domain containing 17B
703828
Mouse
MGI:1917816
226016
Rat
RGD:1305246
309399
Dog
abhydrolase domain containing 17B
VGNC:37466
484170
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 17B
Macaque
abhydrolase domain containing 17B
Mouse
Rat
Dog
abhydrolase domain containing 17B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5VST6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (53)
1 – 10 of 53
C5AR2
Tbio
Family: GPCR
Novelty: 0.01193736
p_int: 0.999466379
p_ni: 0.000533619
p_wrong: 2e-9
Score: 0.167
Data Source: BioPlex,STRINGDB
TCTEX1D2
Tbio
Novelty: 0.15075459
p_int: 0.998646764
p_ni: 0.001345258
p_wrong: 0.000007978
Score: 0.158
Data Source: BioPlex,STRINGDB
UPK2
Tbio
Novelty: 0.01066132
p_int: 0.995489729
p_ni: 0.00432706
p_wrong: 0.000183211
Data Source: BioPlex
TCTEX1D4
Tbio
Novelty: 1.11393549
p_int: 0.994759366
p_ni: 0.005130809
p_wrong: 0.000109825
Data Source: BioPlex
SFTA2
Tdark
Novelty: 0.24469271
p_int: 0.991749225
p_ni: 0.008250761
p_wrong: 1.4e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.988257427
p_ni: 0.011742458
p_wrong: 1.15e-7
Data Source: BioPlex
MAS1
Tchem
Family: GPCR
Novelty: 0.0089712
p_int: 0.978906471
p_ni: 0.020620997
p_wrong: 0.000472532
Data Source: BioPlex
SLC2A12
Tbio
Family: Transporter
Novelty: 0.01455533
p_int: 0.978126503
p_ni: 0.021873496
p_wrong: 1e-9
Data Source: BioPlex
TRIM16L
Tdark
Novelty: 1.32785612
p_int: 0.971406569
p_ni: 0.023477929
p_wrong: 0.005115502
Score: 0.201
Data Source: BioPlex,STRINGDB
FAM174A
Tdark
Novelty: 0.30693139
p_int: 0.956526495
p_ni: 0.043120048
p_wrong: 0.000353457
Data Source: BioPlex
Publication Statistics
PubMed Score  1.31

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer