ABHD17B
Alpha/beta hydrolase domain-containing protein 17B
Protein Summary
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913).
- ENST00000333421
- ENSP00000330222
- ENSG00000107362
- ENST00000377041
- ENSP00000366240
- C9orf77
- FAM108B1
- CGI-67
- C9orf77
- FAM108B1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.8 | ||
histone modification site profile | 0.79 | ||
transcription factor binding site profile | 0.72 | ||
transcription factor | 0.7 | ||
small molecule perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.27 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 33 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.27 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 33 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0