Tbio VPS53 Vacuolar protein sorting-associated protein 53 homolog

Protein Summary

Description

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). This gene encodes a protein with sequence similarity to the yeast Vps53p protein. Vps53p is involved in retrograde vesicle trafficking in late Golgi. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q5VIR6
• A8K2S8
• B3FH42
• Q8WYW3
• Q9BRR2
• Q9BY02
• Q9NV25

Gene Name

• VPS53

Ensembl ID

• ENST00000291074
• ENSP00000291074
• ENSG00000141252
• ENST00000437048
• ENSP00000401435
• ENST00000571805
• ENSP00000459312
• ENST00000638350
• ENSP00000492070
• ENSG00000283883
• ENST00000639801
• ENSP00000492761
• ENST00000639896
• ENSP00000492119

Symbol

• HCCS1
• PCH2E
• hVps53L
• pp13624

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
microRNA	0.9
histone modification site profile	0.89
transcription factor perturbation	0.84
disease perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.09   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.09   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0