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Tbio
RIF1
Telomere-associated protein RIF1

Protein Summary
Description
Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:15342490, PubMed:28241136). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23333306, PubMed:28241136). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (PubMed:28241136). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23333306). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (By similarity). Promotes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243326
  • ENSP00000243326
  • ENSG00000080345
  • ENST00000428287
  • ENSP00000415691
  • ENST00000430328
  • ENSP00000416123
  • ENST00000444746
  • ENSP00000390181
  • ENST00000453091
  • ENSP00000414615
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
transcription factor binding site profile
0.97
transcription factor perturbation
0.88
drug perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
69.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
69.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
replication timing regulatory factor 1
VGNC:2803
459657
Macaque
replication timing regulatory factor 1
694817
Mouse
MGI:1098622
51869
Rat
RGD:1562474
295602
Dog
replication timing regulatory factor 1
VGNC:45575
609234
Species
Name
OMA
EggNOG
Inparanoid
Chimp
replication timing regulatory factor 1
Macaque
replication timing regulatory factor 1
Mouse
Rat
Dog
replication timing regulatory factor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5UIP0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Nonhomologous End-Joining (NHEJ)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Nonhomologous End-Joining (NHEJ)
Gene Ontology Terms (26)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (97)
1 – 10 of 97
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 0.999911338
p_ni: 0.000088662
Score: 0.636
Data Source: BioPlex,STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.998962832
p_ni: 0.001037168
Score: 0.637
Data Source: BioPlex,STRINGDB
ASF1A
Tchem
Novelty: 0.02544466
p_int: 0.997500226
p_ni: 0.002499774
Score: 0.19
Data Source: BioPlex,STRINGDB
ASF1B
Tbio
Novelty: 0.05716701
p_int: 0.940630825
p_ni: 0.059369175
Score: 0.169
Data Source: BioPlex,STRINGDB
TMEM9B
Tdark
Novelty: 0.56628366
p_int: 0.881558229
p_ni: 0.118441771
Data Source: BioPlex
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
p_int: 0.850138284
p_ni: 0.149861716
Data Source: BioPlex
BSG
Tbio
Novelty: 0.0010285
p_int: 0.80280712
p_ni: 0.19719288
Data Source: BioPlex
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
p_int: 0.791075093
p_ni: 0.208924907
Data Source: BioPlex
LAMP3
Tbio
Novelty: 0.01677383
p_int: 0.790568799
p_ni: 0.209431201
Data Source: BioPlex
SCN2B
Tbio
Family: IC
Novelty: 0.03773629
p_int: 0.761449249
p_ni: 0.238550751
Data Source: BioPlex
Publication Statistics
PubMed Score  4.17

PubMed score by year
PubTator Score  147.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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