Tbio EMC10 ER membrane protein complex subunit 10

Protein Summary

Description

Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways.

Uniprot Accession IDs

• Q5UCC4
• Q5UCC6
• Q69YT5
• Q6UWP3
• Q86YL4
• Q8N541

Gene Name

• EMC10

Ensembl ID

• ENST00000334976
• ENSP00000334037
• ENSG00000161671
• ENST00000376918
• ENSP00000366117

Symbol

• C19orf63
• HSM1
• INM02
• HSM1
• HSS1
• C19orf63

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.68
virus perturbation	0.64
transcription factor	0.63
disease perturbation	0.62
transcription factor binding site profile	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.53   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.53   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0