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Tchem
AGBL2
Cytosolic carboxypeptidase 2

Protein Summary
Description
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000525123
  • ENSP00000435582
  • ENSG00000165923
  • ENST00000645431
  • ENSP00000494229
  • ENSG00000285501

Symbol
  • CCP2
  • CCP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
tissue sample
0.6
cell type or tissue
0.58
cell line
0.56
molecular function
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.84   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.84   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3917902
chemical structure image
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
74.3
nervousness
1
1
0
8.1
70.3
worry measurement
1
1
1
60.6
lymphocyte count
1
1
1
45.3
1
1
0
1.1
40.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
74.3
nervousness
0
8.1
70.3
worry measurement
1
60.6
lymphocyte count
1
45.3
0
1.1
40.9
Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (52)
1 – 10 of 52
TPM2
Tbio
Novelty: 0.00406572
p_int: 0.880537227
p_ni: 0.119462773
Score: 0.217
Data Source: BioPlex,STRINGDB
PRTN3
Tchem
Family: Enzyme
Novelty: 0.00022728
Score: 0.807
Data Source: STRINGDB
LXN
Tbio
Family: Enzyme
Novelty: 0.01206819
Score: 0.702
Data Source: STRINGDB
AP3M1
Tbio
Novelty: 0.5036622
Score: 0.688
Data Source: STRINGDB
PSD4
Tbio
Novelty: 0.0674237
Score: 0.686
Data Source: STRINGDB
CPA4
Tbio
Family: Enzyme
Novelty: 0.01439845
Score: 0.674
Data Source: STRINGDB
DDX52
Tbio
Family: Enzyme
Novelty: 0.04618463
Score: 0.672
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.669
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.669
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.669
Data Source: STRINGDB
Publication Statistics
PubMed Score  210.84

PubMed score by year
PubTator Score  142.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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