Tbio HECTD2 Probable E3 ubiquitin-protein ligase HECTD2

Protein Summary

Description

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Uniprot Accession IDs

• Q5U5R9
• Q5VZ97
• Q5VZ98
• Q5VZ99
• Q8N1X7
• Q8TCP5

Gene Name

• HECTD2

Ensembl ID

• ENST00000298068
• ENSP00000298068
• ENSG00000165338
• ENST00000371681
• ENSP00000360746

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
transcription factor binding site profile	0.69
microRNA	0.68
transcription factor perturbation	0.68
virus perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.85   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.85   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0