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Tbio
MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

Protein Summary
Description
E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406189
  • ENSP00000385610
  • ENSG00000176624

Symbol
  • RKHD2
  • RNF194
  • RKHD2
  • BM-013
  • MEX-3C
  • RNF194
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
cell line
0.66
protein domain
0.58
transcription factor
0.57
microRNA
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.88   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.88   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
68.5
mathematical ability
1
1
1
61.5
1
1
0
1
21.7
systolic blood pressure
1
1
1
6.9
Agents acting on the renin-angiotensin system use measurement
1
1
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
68.5
mathematical ability
1
61.5
0
1
21.7
systolic blood pressure
1
6.9
Agents acting on the renin-angiotensin system use measurement
1
2.2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (330)
1 – 10 of 330
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999975392
p_ni: 6.2e-8
p_wrong: 0.000024546
Score: 0.181
Data Source: BioPlex,STRINGDB
LMO2
Tbio
Novelty: 0.0038279
p_int: 0.873112074
p_ni: 2.5e-7
p_wrong: 0.126887675
Score: 0.159
Data Source: BioPlex,STRINGDB
TRIM4
Tbio
Family: Enzyme
Novelty: 0.11398363
Score: 0.958
Data Source: STRINGDB
SPSB1
Tbio
Novelty: 0.13839743
Score: 0.947
Data Source: STRINGDB
RBBP6
Tbio
Family: Enzyme
Novelty: 0.03147368
Score: 0.929
Data Source: STRINGDB
LRRC41
Tbio
Novelty: 0.12601472
Score: 0.926
Data Source: STRINGDB
MGRN1
Tbio
Family: Enzyme
Novelty: 0.04981605
Score: 0.925
Data Source: STRINGDB
DZIP3
Tbio
Family: Enzyme
Novelty: 0.12207819
Score: 0.924
Data Source: STRINGDB
FBXW2
Tbio
Novelty: 0.01492058
Score: 0.924
Data Source: STRINGDB
SPSB2
Tbio
Novelty: 0.07223184
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.88

PubMed score by year
PubTator Score  7.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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