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Tdark
ANKRD45
Ankyrin repeat domain-containing protein 45

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.57   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.57   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
5.5
13.7
1
1
0
1.1
6.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
5.5
13.7
0
1.1
6.8
Protein-Protein Interactions (99)
1 – 10 of 99
HYOU1
Tbio
Novelty: 0.00833649
Score: 0.876
Data Source: STRINGDB
GAK
Tchem
Family: Kinase
Novelty: 0.00731928
Score: 0.871
Data Source: STRINGDB
HSPD1
Tbio
Novelty: 0.00018924
Score: 0.836
Data Source: STRINGDB
HSP90B1
Tchem
Novelty: 0.00135881
Score: 0.826
Data Source: STRINGDB
DNAJC6
Tbio
Family: Enzyme
Novelty: 0.01359669
Score: 0.792
Data Source: STRINGDB
DNAJC3
Tbio
Novelty: 0.02129782
Score: 0.786
Data Source: STRINGDB
SEC63
Tbio
Novelty: 0.00974614
Score: 0.777
Data Source: STRINGDB
CLGN
Tbio
Novelty: 0.06204915
Score: 0.769
Data Source: STRINGDB
CANX
Tbio
Novelty: 0.00087002
Score: 0.769
Data Source: STRINGDB
SURF4
Tbio
Novelty: 0.03230108
Score: 0.735
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.57

PubMed score by year
PubTator Score  0.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer