Tbio CROCC Rootletin

Protein Summary

Description

Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858).

Uniprot Accession IDs

• Q5TZA2
• Q2VHY3
• Q66GT7
• Q7Z2L4
• Q7Z5D7

Gene Name

• CROCC

Ensembl ID

• ENST00000375541
• ENSP00000364691
• ENSG00000058453

Symbol

• KIAA0445
• ROLT
• TAX1BP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.73
cellular component	0.68
interacting protein	0.68
cell line	0.58
tissue	0.52

Protein Classes

PANTHER Classes

Protein / Viral Protein / Rootletin

Protein / Enzyme Modulator / Kinase Modulator / Rootletin

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Rootletin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.9   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.9   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (73)

Explore Interacting Targets

1 – 10 of 73

• See Interactions on String-DB

CROCCP2

Tdark

p_int:  1

Data Source:  BioPlex

XBP1

Tchem

Family:  TF

Novelty:  0.00095584

p_int:  0.999990281

p_ni:  3.23e-7

p_wrong:  0.000009396

Score:  0.383

Data Source:  BioPlex,STRINGDB

PEX14

Tbio

Novelty:  0.0210557

p_int:  0.999532474

p_ni:  0.000467523

p_wrong:  3e-9

Data Source:  BioPlex

TPM1

Tbio

Novelty:  0.00261206

p_int:  0.991825333

p_ni:  0.008174666

Score:  0.213

Data Source:  BioPlex,STRINGDB

PUSL1

Tdark

Family:  Enzyme

Novelty:  2.39739964

p_int:  0.991113786

p_ni:  0.008441057

p_wrong:  0.000445157

Score:  0.177

Data Source:  BioPlex,STRINGDB

SRBD1

Tbio

Novelty:  0.18931356

p_int:  0.988469515

p_ni:  0.011529773

p_wrong:  7.12e-7

Score:  0.183

Data Source:  BioPlex,STRINGDB

EPS15L1

Tbio

Novelty:  0.06929299

p_int:  0.986008943

p_ni:  0.013991057

Data Source:  BioPlex

RALBP1

Tbio

Novelty:  0.01525176

p_int:  0.972744704

p_ni:  0.027255296

Data Source:  BioPlex

SCGN

Tbio

Novelty:  0.01434518

p_int:  0.966634135

p_ni:  0.033365865

Score:  0.521

Data Source:  BioPlex,STRINGDB

UBR1

Tbio

Family:  Enzyme

Novelty:  0.00998888

p_int:  0.943436758

p_ni:  0.056563242

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (3)

Components (8)

Processes (10)

Find Similar Targets

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1 – 3 of 3

GO Term	Evidence	Assigned by
kinesin binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
structural molecule activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
actin binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (21)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 21

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	8	18	37		95.1
BMI-adjusted hip circumference	EFO_0008039	3	17	19		94.6
body height	EFO_0004339	5	3	7		94.6
waist circumference	EFO_0004342	1	7	7		81.3
hematocrit	EFO_0004348	2	2	2		76.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 21

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	37		95.1
BMI-adjusted hip circumference	EFO_0008039	19		94.6
body height	EFO_0004339	7		94.6
waist circumference	EFO_0004342	7		81.3
hematocrit	EFO_0004348	2		76.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell cycle
Cell projection
Cilium
Cilium biogenesis/degradation
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
anthropometric measurement
BMI-adjusted hip circumference
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body fat distribution
body height
body mass index
chronic obstructive pulmonary disease
cortical surface area measurement
FEV/FEC ratio

MGI Phenotype Find Similar Targets

No Header	No Header
immune system phenotype
nervous system phenotype
respiratory system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ciliary rootlet coiled-coil, rootletin	VGNC:11307	456523
Macaque	ciliary rootlet coiled-coil, rootletin		710793
Mouse	ciliary rootlet coiled-coil, rootletin	MGI:3529431	230872
Rat	ciliary rootlet coiled-coil, rootletin	RGD:1305364	313663
Dog	ciliary rootlet coiled-coil, rootletin	VGNC:54719	487417

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ciliary rootlet coiled-coil, rootletin
Macaque	ciliary rootlet coiled-coil, rootletin
Mouse	ciliary rootlet coiled-coil, rootletin
Rat	ciliary rootlet coiled-coil, rootletin
Dog	ciliary rootlet coiled-coil, rootletin

Publication Statistics

PubMed Score 26.90

PubMed score by year

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PubTator Score 14.48

PubTator score by year

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Related Publications

Text Mined References (25)

GeneRif Annotations (7)

Items per page:

10

0 of 0

PMID	Year	Title