Protein Summary
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858).
- ENST00000375541
- ENSP00000364691
- ENSG00000058453
- KIAA0445
- ROLT
- TAX1BP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor | 0.73 | ||
cellular component | 0.68 | ||
interacting protein | 0.68 | ||
cell line | 0.58 | ||
tissue | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.9 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 30 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.9 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 30 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (73)
XBP1
Family: TF
Novelty: 0.00095584
p_int: 0.999990281
p_ni: 3.23e-7
p_wrong: 0.000009396
Score: 0.383
Data Source: BioPlex,STRINGDB
TPM1
Novelty: 0.00261206
p_int: 0.991825333
p_ni: 0.008174666
Score: 0.213
Data Source: BioPlex,STRINGDB
PUSL1
Family: Enzyme
Novelty: 2.39739964
p_int: 0.991113786
p_ni: 0.008441057
p_wrong: 0.000445157
Score: 0.177
Data Source: BioPlex,STRINGDB
SRBD1
Novelty: 0.18931356
p_int: 0.988469515
p_ni: 0.011529773
p_wrong: 7.12e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
SCGN
Novelty: 0.01434518
p_int: 0.966634135
p_ni: 0.033365865
Score: 0.521
Data Source: BioPlex,STRINGDB
UBR1
Family: Enzyme
Novelty: 0.00998888
p_int: 0.943436758
p_ni: 0.056563242
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (3)
Components (8)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 8 | 18 | 37 | 95.1 | |||||
BMI-adjusted hip circumference | 3 | 17 | 19 | 94.6 | |||||
body height | 5 | 3 | 7 | 94.6 | |||||
waist circumference | 1 | 7 | 7 | 81.3 | |||||
hematocrit | 2 | 2 | 2 | 76.2 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 37 | 95.1 | |||||
BMI-adjusted hip circumference | 19 | 94.6 | |||||
body height | 7 | 94.6 | |||||
waist circumference | 7 | 81.3 | |||||
hematocrit | 2 | 76.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ciliary rootlet coiled-coil, rootletin | VGNC:11307 | 456523 | |||||
Macaque | ciliary rootlet coiled-coil, rootletin | 710793 | ||||||
Mouse | MGI:3529431 | 230872 | ||||||
Rat | RGD:1305364 | 313663 | ||||||
Dog | ciliary rootlet coiled-coil, rootletin | VGNC:54719 | 487417 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ciliary rootlet coiled-coil, rootletin | |||||
Macaque | ciliary rootlet coiled-coil, rootletin | |||||
Mouse | ||||||
Rat | ||||||
Dog | ciliary rootlet coiled-coil, rootletin | |||||
Publication Statistics
PubMed Score 26.90
PubMed score by year
PubTator Score 14.48
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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