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Tbio
CROCC
Rootletin

Protein Summary
Description
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375541
  • ENSP00000364691
  • ENSG00000058453

Symbol
  • KIAA0445
  • ROLT
  • TAX1BP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.73
cellular component
0.68
interacting protein
0.68
cell line
0.58
tissue
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.9   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.9   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
8
18
37
95.1
BMI-adjusted hip circumference
3
17
19
94.6
body height
5
3
7
94.6
waist circumference
1
7
7
81.3
hematocrit
2
2
2
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
37
95.1
BMI-adjusted hip circumference
19
94.6
body height
7
94.6
waist circumference
7
81.3
hematocrit
2
76.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ciliary rootlet coiled-coil, rootletin
VGNC:11307
456523
Macaque
ciliary rootlet coiled-coil, rootletin
710793
Mouse
MGI:3529431
230872
Rat
RGD:1305364
313663
Dog
ciliary rootlet coiled-coil, rootletin
VGNC:54719
487417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ciliary rootlet coiled-coil, rootletin
Macaque
ciliary rootlet coiled-coil, rootletin
Mouse
Rat
Dog
ciliary rootlet coiled-coil, rootletin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5TZA2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (73)
1 – 10 of 73
CROCCP2
Tdark
p_int:  1
Data Source:  BioPlex
XBP1
Tchem
Family:  TF
Novelty:  0.00095584
p_int:  0.999990281
p_ni:  3.23e-7
p_wrong:  0.000009396
Score:  0.383
Data Source:  BioPlex,STRINGDB
PEX14
Tbio
Novelty:  0.0210557
p_int:  0.999532474
p_ni:  0.000467523
p_wrong:  3e-9
Data Source:  BioPlex
TPM1
Tbio
Novelty:  0.00261206
p_int:  0.991825333
p_ni:  0.008174666
Score:  0.213
Data Source:  BioPlex,STRINGDB
PUSL1
Tdark
Family:  Enzyme
Novelty:  2.39739964
p_int:  0.991113786
p_ni:  0.008441057
p_wrong:  0.000445157
Score:  0.177
Data Source:  BioPlex,STRINGDB
SRBD1
Tbio
Novelty:  0.18931356
p_int:  0.988469515
p_ni:  0.011529773
p_wrong:  7.12e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.986008943
p_ni:  0.013991057
Data Source:  BioPlex
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.972744704
p_ni:  0.027255296
Data Source:  BioPlex
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.966634135
p_ni:  0.033365865
Score:  0.521
Data Source:  BioPlex,STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.943436758
p_ni:  0.056563242
Data Source:  BioPlex
Publication Statistics
PubMed Score  26.90

PubMed score by year
PubTator Score  14.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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