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Tbio
LIN9
Protein lin-9 homolog

Protein Summary
Description
Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328205
  • ENSP00000329102
  • ENSG00000183814

Symbol
  • BARA
  • TGS
  • TGS
  • BARA
  • TGS1
  • TGS2
  • Lin-9
  • BARPsv
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor binding site profile
0.72
tissue
0.65
transcription factor perturbation
0.61
virus perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.68   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.68   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
3
3
71.4
telomere length
2
1
3
70.2
sex hormone-binding globulin measurement
5
1
5
69.8
mean platelet volume
2
1
2
61.4
mean corpuscular hemoglobin concentration
1
1
1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
71.4
telomere length
3
70.2
sex hormone-binding globulin measurement
5
69.8
mean platelet volume
2
61.4
mean corpuscular hemoglobin concentration
1
56.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lin-9 DREAM MuvB core complex component
VGNC:8388
469689
Macaque
lin-9 DREAM MuvB core complex component
699056
Mouse
MGI:1919818
72568
Rat
RGD:1591104
689523
Dog
lin-9 DREAM MuvB core complex component
VGNC:42687
611881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lin-9 DREAM MuvB core complex component
Macaque
lin-9 DREAM MuvB core complex component
Mouse
Rat
Dog
lin-9 DREAM MuvB core complex component
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5TKA1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin E associated events during G1/S transition
Reactome
G0 and Early G1
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A:Cdk2-associated events at S phase entry
Cyclin E associated events during G1/S transition
G0 and Early G1
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (85)
1 – 10 of 85
LIN37
Tdark
Novelty:  0.27040489
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
MYBL2
Tbio
Family:  TF
Novelty:  0.00405647
p_int:  0.999999995
p_ni:  5e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
MYBL1
Tbio
Family:  TF
Novelty:  0.00695014
p_int:  0.999999988
p_ni:  1.2e-8
Score:  0.926
Data Source:  BioPlex,STRINGDB
LIN54
Tbio
Novelty:  0.06173892
p_int:  0.999998709
p_ni:  0.00000129
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
LIN52
Tbio
Novelty:  0.08105335
p_int:  0.99998444
p_ni:  1.89e-7
p_wrong:  0.000015371
Score:  0.999
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999960014
p_ni:  0.000039986
Score:  0.827
Data Source:  BioPlex,STRINGDB
DIS3L
Tbio
Family:  Enzyme
Novelty:  0.12886408
p_int:  0.999583474
p_ni:  0.000416523
p_wrong:  3e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
PHF20L1
Tbio
Family:  Epigenetic
Novelty:  0.23101523
p_int:  0.998483559
p_ni:  0.001516438
p_wrong:  2e-9
Score:  0.739
Data Source:  BioPlex,STRINGDB
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.998118351
p_ni:  0.001881649
Data Source:  BioPlex
RGS13
Tbio
Novelty:  0.11219302
p_int:  0.99675776
p_ni:  0.00324224
Score:  0.189
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  95.68

PubMed score by year
PubTator Score  65.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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