EFCAB6
EF-hand calcium-binding domain-containing protein 6
Protein Summary
Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
- ENST00000262726
- ENSP00000262726
- ENSG00000186976
- ENST00000396231
- ENSP00000379533
- DJBP
- KIAA1672
- DJBP
- HSCBCIP1
- dJ185D5.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.78 | ||
gene perturbation | 0.69 | ||
virus perturbation | 0.68 | ||
transcription factor | 0.63 | ||
disease perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.24 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 26 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.24 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 26 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0