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Tdark
EFCAB6
EF-hand calcium-binding domain-containing protein 6

Protein Summary
Description
Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262726
  • ENSP00000262726
  • ENSG00000186976
  • ENST00000396231
  • ENSP00000379533

Symbol
  • DJBP
  • KIAA1672
  • DJBP
  • HSCBCIP1
  • dJ185D5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
gene perturbation
0.69
virus perturbation
0.68
transcription factor
0.63
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.05   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.05   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
91.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
91.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EF-hand calcium binding domain 6
VGNC:5256
458892
Macaque
EF-hand calcium binding domain 6
712043
Mouse
MGI:1924877
77627
Rat
RGD:1309065
315179
Dog
EF-hand calcium binding domain 6
VGNC:40217
481218
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EF-hand calcium binding domain 6
Macaque
EF-hand calcium binding domain 6
Mouse
Rat
Dog
EF-hand calcium binding domain 6
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5THR3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (44)
1 – 10 of 44
PARK7
Tbio
Family: Enzyme
Novelty: 0.00104651
Score: 0.677
Data Source: STRINGDB
PIAS2
Tbio
Family: TF
Novelty: 0.0116785
Score: 0.672
Data Source: STRINGDB
DLGAP3
Tbio
Novelty: 0.02019435
Score: 0.655
Data Source: STRINGDB
ACTL9
Tdark
Novelty: 0.33211557
Score: 0.636
Data Source: STRINGDB
MYH10
Tbio
Novelty: 0.00624251
Score: 0.634
Data Source: STRINGDB
DENND5A
Tbio
Novelty: 0.18606309
Score: 0.615
Data Source: STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.607
Data Source: STRINGDB
SPEG
Tbio
Family: Kinase
Novelty: 0.01666376
Score: 0.601
Data Source: STRINGDB
OBSCN
Tbio
Family: Kinase
Novelty: 0.01173699
Score: 0.601
Data Source: STRINGDB
SIPA1L1
Tdark
Novelty: 0.13134052
Score: 0.59
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.05

PubMed score by year
PubTator Score  1.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer