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Tdark
PRR14L
Protein PRR14L

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.06   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.06   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (27)
1 – 10 of 27
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.846650672
p_ni:  0.153349328
Score:  0.173
Data Source:  BioPlex,STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.83414326
p_ni:  0.16585674
Score:  0.254
Data Source:  BioPlex,STRINGDB
STK35
Tchem
Family:  Kinase
Novelty:  0.19556072
p_int:  0.807537083
p_ni:  0.192462917
Score:  0.345
Data Source:  BioPlex,STRINGDB
GADD45A
Tbio
Novelty:  0.00178533
p_int:  0.798383178
p_ni:  0.201616822
Data Source:  BioPlex
QSER1
Tdark
Novelty:  0.62017582
Score:  0.738
Data Source:  STRINGDB
NHLRC3
Tdark
Novelty:  1.23813202
Score:  0.736
Data Source:  STRINGDB
TMTC3
Tdark
Novelty:  0.17411457
Score:  0.729
Data Source:  STRINGDB
ZDHHC21
Tbio
Family:  Enzyme
Novelty:  0.11768266
Score:  0.642
Data Source:  STRINGDB
RBM27
Tdark
Novelty:  0.04875536
Score:  0.628
Data Source:  STRINGDB
YWHAH
Tchem
Novelty:  0.01000071
Score:  0.626
Data Source:  STRINGDB
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
1
1
59.6
reticulocyte measurement
1
1
1
56.4
lymphocyte count
2
1
2
45.7
2
2
1
1.1
43.9
1
2
0
1.3
42.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
59.6
reticulocyte measurement
1
56.4
lymphocyte count
2
45.7
1
1.1
43.9
0
1.3
42.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proline rich 14 like
VGNC:6707
458774
Macaque
proline rich 14 like
716931
Mouse
MGI:2443658
215476
Rat
RGD:1305469
305466
Dog
proline rich 14 like
VGNC:45039
477545
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proline rich 14 like
Macaque
proline rich 14 like
Mouse
Rat
Dog
proline rich 14 like
Publication Statistics
PubMed Score 1.06
PubMed score by year
PubTator Score 0.17
PubTator score by year