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Tdark
MINOS1
MICOS complex subunit MIC10

Protein Summary
Description
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322753
  • ENSP00000325562
  • ENSG00000173436

Symbol
  • C1orf151
  • MIC10
  • MIO10
  • Mic10
  • MINOS1
  • C1orf151
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.92
cell type or tissue
0.86
histone modification site profile
0.77
transcription factor perturbation
0.74
transcription factor
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
83.7
hormone measurement
1
1
3
82.1
waist-hip ratio
1
1
1
67
body mass index
1
1
1
65.8
2
2
1
1.1
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
83.7
hormone measurement
3
82.1
waist-hip ratio
1
67
body mass index
1
65.8
1
1.1
65.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial inner membrane organizing system 1
VGNC:11536
743251
Mouse
MGI:1913628
433771
Dog
mitochondrial inner membrane organizing system 1
612968
Horse
mitochondrial inner membrane organizing system 1
100630569
Pig
mitochondrial inner membrane organizing system 1
100623381
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial inner membrane organizing system 1
Mouse
Dog
mitochondrial inner membrane organizing system 1
Horse
mitochondrial inner membrane organizing system 1
Pig
mitochondrial inner membrane organizing system 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5TGZ0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (72)
1 – 10 of 72
MTX2
Tbio
Novelty: 0.02047483
Score: 0.99
Data Source: STRINGDB
MTX1
Tbio
Novelty: 0.02350764
Score: 0.987
Data Source: STRINGDB
IMMT
Tbio
Novelty: 0.00260309
Score: 0.986
Data Source: STRINGDB
SAMM50
Tbio
Novelty: 0.00553631
Score: 0.982
Data Source: STRINGDB
CHCHD3
Tbio
Novelty: 0.05341939
Score: 0.982
Data Source: STRINGDB
DNAJC11
Tbio
Novelty: 0.31080011
Score: 0.977
Data Source: STRINGDB
APOO
Tbio
Novelty: 0.04964756
Score: 0.975
Data Source: STRINGDB
APOOL
Tbio
Novelty: 0.08233023
Score: 0.973
Data Source: STRINGDB
MIC13
Tbio
Novelty: 0.03686888
Score: 0.97
Data Source: STRINGDB
CHCHD6
Tbio
Novelty: 0.12379343
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.25

PubMed score by year
PubTator Score  21.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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