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Tbio
HES3
Transcription factor HES-3

Protein Summary
Description
Transcriptional repressor of genes that require a bHLH protein for their transcription.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377898
  • ENSP00000367130
  • ENSG00000173673

Symbol
  • BHLHB43
  • bHLHb43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
transcription factor
0.81
biological process
0.77
transcription factor binding site profile
0.72
gene perturbation
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104877
15207
Rat
RGD:621339
64628
Dog
hes family bHLH transcription factor 3
VGNC:49829
489629
Horse
hes family bHLH transcription factor 3
VGNC:50701
100147590
Cow
hes family bHLH transcription factor 3
VGNC:29820
615356
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
hes family bHLH transcription factor 3
Horse
hes family bHLH transcription factor 3
Cow
hes family bHLH transcription factor 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5TGS1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (22)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (29)
1 – 10 of 29
HES6
Tbio
Family: TF
Novelty: 0.01546524
Score: 0.598
Data Source: STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.59
Data Source: STRINGDB
SPATA31D1
Tdark
Novelty: 1.43869343
Score: 0.567
Data Source: STRINGDB
HEY1
Tbio
Family: TF
Novelty: 0.0042366
Score: 0.563
Data Source: STRINGDB
HEYL
Tbio
Family: TF
Novelty: 0.00643194
Score: 0.547
Data Source: STRINGDB
POU5F1
Tbio
Family: TF
Novelty: 0.00033974
Score: 0.533
Data Source: STRINGDB
MAMLD1
Tbio
Novelty: 0.01681081
Score: 0.516
Data Source: STRINGDB
HELT
Tbio
Family: TF
Novelty: 0.03704503
Score: 0.516
Data Source: STRINGDB
ASCL1
Tbio
Family: TF
Novelty: 0.00274239
Score: 0.515
Data Source: STRINGDB
NKAIN3
Tdark
Family: Enzyme
Novelty: 0.3456674
Score: 0.515
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.38

PubMed score by year
PubTator Score  25.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer