You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
MFSD4B
Sodium-dependent glucose transporter 1

Protein Summary
Description
May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368847
  • ENSP00000357840
  • ENSG00000173214

Symbol
  • KIAA1919
  • NAGLT1
  • NaGLT1
  • KIAA1919
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.78   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.78   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
3
3
2
1.1
99
3
3
0
1.3
93.8
smoking initiation
2
1
2
86.6
smoking behaviour measurement
1
1
1
85.7
1
1
0
6.7
79.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1.1
99
0
1.3
93.8
smoking initiation
2
86.6
smoking behaviour measurement
1
85.7
0
6.7
79.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 4B
VGNC:3260
472095
Macaque
major facilitator superfamily domain containing 4B
696009
Rat
RGD:1304770
309810
Dog
major facilitator superfamily domain containing 4B
VGNC:54325
481962
Horse
major facilitator superfamily domain containing 4B
VGNC:51055
100072387
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major facilitator superfamily domain containing 4B
Macaque
major facilitator superfamily domain containing 4B
Rat
Dog
major facilitator superfamily domain containing 4B
Horse
major facilitator superfamily domain containing 4B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5TF39-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
SLC-mediated transmembrane transport
Transport of small molecules
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (74)
1 – 10 of 74
GNAI2
Tbio
Novelty: 0.03014729
p_int: 0.978902856
p_ni: 0.01356293
p_wrong: 0.007534214
Score: 0.173
Data Source: BioPlex,STRINGDB
PRKAG1
Tbio
Family: Kinase
Novelty: 0.07735301
p_int: 0.937730028
p_ni: 0.017049091
p_wrong: 0.045220881
Score: 0.193
Data Source: BioPlex,STRINGDB
DHRS9
Tbio
Family: Enzyme
Novelty: 0.00256743
p_int: 0.927578194
p_ni: 0.025853563
p_wrong: 0.046568243
Score: 0.201
Data Source: BioPlex,STRINGDB
DPH6
Tbio
Family: Enzyme
Novelty: 0.15211179
p_int: 0.898477974
p_ni: 0.026061674
p_wrong: 0.075460352
Score: 0.519
Data Source: BioPlex,STRINGDB
ATP6V0D1
Tbio
Family: Enzyme
Novelty: 0.05146108
p_int: 0.868777996
p_ni: 0.053461725
p_wrong: 0.077760279
Score: 0.203
Data Source: BioPlex,STRINGDB
EIF2B2
Tbio
Novelty: 0.03253919
p_int: 0.868777996
p_ni: 0.053461725
p_wrong: 0.077760279
Score: 0.179
Data Source: BioPlex,STRINGDB
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.83548213
p_ni: 0.002012433
p_wrong: 0.162505437
Score: 0.22
Data Source: BioPlex,STRINGDB
SLC5A1
Tclin
Family: Transporter
Novelty: 0.00113611
Score: 0.834
Data Source: STRINGDB
MFSD11
Tdark
Novelty: 0.13167358
Score: 0.78
Data Source: STRINGDB
MFSD10
Tbio
Novelty: 0.12830664
Score: 0.774
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.78

PubMed score by year
PubTator Score  7.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: