Tbio NDUFAF5 Arginine-hydroxylase NDUFAF5, mitochondrial

Protein Summary

Description

Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages (PubMed:18940309, PubMed:27226634). Acts by mediating hydroxylation of 'Arg-111' of NDUFS7 (PubMed:27226634). May also have methyltransferase activity (Probable). The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes a mitochondrial protein that is associated with the matrix face of the mitochondrial inner membrane and is required for complex I assembly. A mutation in this gene results in mitochondrial complex I deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q5TEU4
• A8K166
• Q6GPH3
• Q9H6F4

Gene Name

• NDUFAF5

Ensembl ID

• ENST00000378106
• ENSP00000367346
• ENSG00000101247
• ENST00000463598
• ENSP00000420497

Symbol

• C20orf7
• C20orf7
• MC1DN16
• dJ842G6.1
• bA526K24.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
cell type or tissue	0.74
transcription factor binding site profile	0.69
cellular component	0.65
cell line	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.83   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.83   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0