Tbio SH3PXD2A SH3 and PX domain-containing protein 2A

Protein Summary

Description

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.

Uniprot Accession IDs

• Q5TCZ1
• D3DR98
• O43302
• Q5TCZ2
• Q5TDQ8

Gene Name

• SH3PXD2A

Ensembl ID

• ENST00000355946
• ENSP00000348215
• ENSG00000107957
• ENST00000369774
• ENSP00000358789

Symbol

• FISH
• KIAA0418
• SH3MD1
• TKS5
• FISH
• TKS5
• SH3MD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.81
transcription factor binding site profile	0.7
transcription factor perturbation	0.68
histone modification site profile	0.64
virus perturbation	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.57   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 135   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.57   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0