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Tbio
SH3PXD2A
SH3 and PX domain-containing protein 2A

Protein Summary
Description
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355946
  • ENSP00000348215
  • ENSG00000107957
  • ENST00000369774
  • ENSP00000358789

Symbol
  • FISH
  • KIAA0418
  • SH3MD1
  • TKS5
  • FISH
  • TKS5
  • SH3MD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.81
transcription factor binding site profile
0.7
transcription factor perturbation
0.68
histone modification site profile
0.64
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.83   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.83   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
6
0
1.2
98.4
telomere length
6
5
6
92.7
3
3
1
1.1
87.5
4
3
0
1.2
79.3
white matter hyperintensity measurement
6
3
8
7.2
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
98.4
telomere length
6
92.7
1
1.1
87.5
0
1.2
79.3
white matter hyperintensity measurement
8
7.2
78.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SH3 and PX domains 2A
714868
Mouse
MGI:1298393
14218
Rat
RGD:1311185
309460
Dog
SH3 and PX domains 2A
VGNC:46130
486874
Horse
SH3 and PX domains 2A
VGNC:22945
100059600
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SH3 and PX domains 2A
Mouse
Rat
Dog
SH3 and PX domains 2A
Horse
SH3 and PX domains 2A
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5TCZ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Invadopodia formation
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Invadopodia formation
Gene Ontology Terms (15)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (61)
1 – 10 of 61
ZNF764
Tdark
Family:  TF
Novelty:  0.76308829
p_int:  1
Score:  0.37
Data Source:  BioPlex,STRINGDB
ADAM15
Tbio
Family:  Enzyme
Novelty:  0.01144571
Score:  0.948
Data Source:  Reactome,STRINGDB
ADAM12
Tchem
Family:  Enzyme
Novelty:  0.0045095
Score:  0.946
Data Source:  Reactome,STRINGDB
GSN
Tbio
Novelty:  0.00060852
Score:  0.935
Data Source:  STRINGDB
ADAM19
Tbio
Family:  Enzyme
Novelty:  0.01830281
Score:  0.925
Data Source:  Reactome,STRINGDB
FSCN1
Tchem
Novelty:  0.00221877
Score:  0.923
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.921
Data Source:  STRINGDB
KIF9
Tbio
Novelty:  0.12089339
Score:  0.912
Data Source:  STRINGDB
CTTN
Tbio
Novelty:  0.0017962
Score:  0.909
Data Source:  STRINGDB
LCP1
Tbio
Novelty:  0.0035357
Score:  0.906
Data Source:  STRINGDB
Publication Statistics
PubMed Score  48.83

PubMed score by year
PubTator Score  31.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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