Tbio TTBK1 Tau-tubulin kinase 1

Protein Summary

Description

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. Summary:This gene belongs to the casein kinase 1 superfamily. The encoded protein is a neuron-specific, serine/threonine and tyrosine kinase, which regulates phosphorylation of tau, a protein that associates with microtubule assemblies and stabilizes them. Genetic variants in this gene are associated with Alzheimer's disease. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q5TCY1
• A2A2U5
• Q2L6C6
• Q6ZNH0
• Q8N444
• Q96JH2

Gene Name

• TTBK1

Ensembl ID

• ENST00000259750
• ENSP00000259750
• ENSG00000146216

Symbol

• BDTK
• KIAA1855
• BDTK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
tissue sample	0.74
microRNA	0.72
cell line	0.55
metabolite	0.45

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Tau-tubulin Kinase 1

DTO Classes

Protein / Kinase / Protein Kinase / Ck1 Group / Ttbk Family / Tau-tubulin Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.64   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.64   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0