You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAP3K21
Mitogen-activated protein kinase kinase kinase 21

Protein Summary
Description
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366622
  • ENSP00000355581
  • ENSG00000143674
  • ENST00000366623
  • ENSP00000355582
  • ENST00000366624
  • ENSP00000355583

Symbol
  • KIAA1804
  • MLK4
  • MLK4
  • dJ862P8.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.47   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.47   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: inoh
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
PathwayCommons: inoh
VEGF signaling pathway ( VEGF signaling pathway )
PathwayCommons: inoh
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
PathwayCommons: inoh
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )
PathwayCommons: inoh
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Name
Explore in Pharos
Explore in Source
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
VEGF signaling pathway ( VEGF signaling pathway )
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (12)
1 – 10 of 12
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.999997196
p_ni: 0.000002798
p_wrong: 6e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
SLX1A
Tbio
Family: Enzyme
Novelty: 0.0310173
p_int: 0.99759516
p_ni: 0.000026645
p_wrong: 0.002378195
Data Source: BioPlex
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.918911369
p_ni: 0.000042568
p_wrong: 0.081046062
Score: 0.195
Data Source: BioPlex,STRINGDB
PTPRK
Tbio
Family: Enzyme
Novelty: 0.03149943
Score: 0.597
Data Source: STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.579
Data Source: STRINGDB
RSPO2
Tbio
Novelty: 0.0188211
Score: 0.538
Data Source: STRINGDB
CDC7
Tchem
Family: Kinase
Novelty: 0.00435359
Score: 0.449
Data Source: STRINGDB
PEX14
Tbio
Novelty: 0.0210557
Score: 0.448
Data Source: STRINGDB
SLC26A3
Tbio
Family: Transporter
Novelty: 0.00157687
Score: 0.435
Data Source: STRINGDB
MAP2K4
Tchem
Family: Kinase
Novelty: 0.00252847
Score: 0.429
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.47

PubMed score by year
PubTator Score  6.35

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer