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Tbio
AK9
Adenylate kinase 9

Protein Summary
Description
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP. The protein encoded by this gene catalyzes the interconversion of nucleosides, possessing both nucleoside monophosphate and diphosphate kinase activities. The encoded protein uses these interconversions to maintain nucleoside homeostasis. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285397
  • ENSP00000285397
  • ENSG00000155085
  • ENST00000355283
  • ENSP00000347431
  • ENST00000424296
  • ENSP00000410186

Symbol
  • AKD1
  • AKD2
  • C6orf199
  • C6orf224
  • AK 9
  • AKD1
  • AKD2
  • C6orf199
  • C6orf224
  • dJ70A9.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
biological process
0.77
histone modification site profile
0.74
tissue sample
0.66
cellular component
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.91   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.91   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
64.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
64.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2685080
633979
Rat
RGD:1559879
294521
Dog
adenylate kinase 9
VGNC:37750
475022
Cow
adenylate kinase 9
VGNC:25778
504511
Opossum
adenylate kinase 9
100029154
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
adenylate kinase 9
Cow
adenylate kinase 9
Opossum
adenylate kinase 9
Pathways (6)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Protein-Protein Interactions (194)
1 – 10 of 194
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
p_int: 0.943955181
p_ni: 0.050653838
p_wrong: 0.005390981
Score: 0.189
Data Source: BioPlex,STRINGDB
LRRC23
Tdark
Novelty: 0.67210911
p_int: 0.912761039
p_ni: 2.1e-8
p_wrong: 0.08723894
Score: 0.548
Data Source: BioPlex,STRINGDB
EXOG
Tbio
Family: Enzyme
Novelty: 0.03588463
p_int: 0.912656854
p_ni: 0.087343109
p_wrong: 3.7e-8
Score: 0.16
Data Source: BioPlex,STRINGDB
C5orf34
Tdark
Novelty: 1.01063928
p_int: 0.902480033
p_ni: 0.094861069
p_wrong: 0.002658898
Data Source: BioPlex
HDAC3
Tclin
Family: Epigenetic
Novelty: 0.00393172
p_int: 0.882233655
p_ni: 0.108764793
p_wrong: 0.009001552
Score: 0.21
Data Source: BioPlex,STRINGDB
TAF2
Tbio
Novelty: 0.0397428
p_int: 0.856569297
p_ni: 0.061336203
p_wrong: 0.0820945
Score: 0.209
Data Source: BioPlex,STRINGDB
MYO9A
Tbio
Novelty: 0.09467086
p_int: 0.838075779
p_ni: 0.161924221
Score: 0.226
Data Source: BioPlex,STRINGDB
PRIM1
Tbio
Family: Enzyme
Novelty: 0.0530384
p_int: 0.79705931
p_ni: 0.20294069
Score: 0.775
Data Source: BioPlex,STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.961
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.91

PubMed score by year
PubTator Score  6.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer