MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Protein Summary
Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.
- ENST00000307546
- ENSP00000304604
- ENSG00000081026
- ENST00000369611
- ENSP00000358624
- ENST00000369615
- ENSP00000358628
- ENST00000369617
- ENSP00000358630
- KIAA1634
- MAGI-3
- dJ730K3.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.97 | ||
protein domain | 0.92 | ||
transcription factor binding site profile | 0.84 | ||
histone modification site profile | 0.83 | ||
microRNA | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.36 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 60 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.36 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 60 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0