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Tbio
CYP4A22
Cytochrome P450 4A22

Protein Summary
Description
Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371891
  • ENSP00000360958
  • ENSG00000162365
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
molecular function
0.63
cell line
0.62
pathway
0.62
gene perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.92   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.92   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
CYP4A11
Tbio
Novelty:  0.01121493
p_int:  1
Score:  0.939
Data Source:  BioPlex,STRINGDB
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
Score:  0.696
Data Source:  STRINGDB
ALDH9A1
Tbio
Family:  Enzyme
Novelty:  0.01688006
Score:  0.692
Data Source:  STRINGDB
ALDH1B1
Tchem
Family:  Enzyme
Novelty:  0.01755208
Score:  0.678
Data Source:  STRINGDB
ALDH7A1
Tbio
Family:  Enzyme
Novelty:  0.00069494
Score:  0.678
Data Source:  STRINGDB
ALDH3A2
Tbio
Family:  Enzyme
Novelty:  0.0059198
Score:  0.677
Data Source:  STRINGDB
PPIG
Tchem
Family:  Enzyme
Novelty:  0.00014569
Score:  0.663
Data Source:  STRINGDB
PTGIS
Tchem
Family:  Enzyme
Novelty:  0.00183292
Score:  0.623
Data Source:  STRINGDB
FA2H
Tbio
Family:  Enzyme
Novelty:  0.00449208
Score:  0.594
Data Source:  STRINGDB
POR
Tbio
Family:  Enzyme
Novelty:  0.00145147
Score:  0.577
Data Source:  STRINGDB
Pathways (22)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Eicosanoids
Reactome
Fatty acid metabolism
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Eicosanoids
Fatty acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
85.4
red blood cell distribution width
2
2
2
71.4
mean platelet volume
2
2
2
70.1
body mass index
4
2
4
69.6
mean reticulocyte volume
1
1
1
48.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
85.4
red blood cell distribution width
2
71.4
mean platelet volume
2
70.1
body mass index
4
69.6
mean reticulocyte volume
1
48.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily A member 22
VGNC:13000
456835
Mouse
MGI:3028580
666168
Mouse
MGI:88611
13117
Rat
RGD:68945
50549
Dog
cytochrome P450 4A37
482506
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily A member 22
Mouse
Mouse
Rat
Dog
cytochrome P450 4A37
Publication Statistics
PubMed Score 79.92
PubMed score by year
PubTator Score 4.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title