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Tbio
RNASEH2B
Ribonuclease H2 subunit B

Protein Summary
Description
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336617
  • ENSP00000337623
  • ENSG00000136104
  • ENST00000422660
  • ENSP00000389877

Symbol
  • DLEU8
  • AGS2
  • DLEU8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor perturbation
0.84
transcription factor binding site profile
0.78
biological process
0.6
cell line
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.44   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.44   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
46.8
systolic blood pressure
1
1
1
44.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
46.8
systolic blood pressure
1
44.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease H2 subunit B
VGNC:5101
452726
Macaque
ribonuclease H2 subunit B
707995
Mouse
MGI:1914403
67153
Rat
RGD:1359710
361056
Dog
ribonuclease H2 subunit B
VGNC:45613
607281
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease H2 subunit B
Macaque
ribonuclease H2 subunit B
Mouse
Rat
Dog
ribonuclease H2 subunit B
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (47)
1 – 10 of 47
RNASEH2C
Tbio
Family: Enzyme
Novelty: 0.06148299
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
RNASEH2A
Tbio
Family: Enzyme
Novelty: 0.00478657
Score: 0.999
Data Source: STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.975
Data Source: STRINGDB
SAMHD1
Tbio
Family: Enzyme
Novelty: 0.00294595
Score: 0.86
Data Source: STRINGDB
AP1M1
Tbio
Novelty: 0.029282
Score: 0.847
Data Source: STRINGDB
FAM124A
Tdark
Novelty: 1.51577847
Score: 0.75
Data Source: STRINGDB
TREX1
Tbio
Family: Enzyme
Novelty: 0.87486677
Score: 0.748
Data Source: STRINGDB
ADAR
Tbio
Family: Enzyme
Novelty: 0.00135586
Score: 0.684
Data Source: STRINGDB
FEN1
Tchem
Family: Enzyme
Novelty: 0.00082515
Score: 0.669
Data Source: STRINGDB
RIF1
Tbio
Novelty: 0.34360368
Score: 0.645
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.44

PubMed score by year
PubTator Score  13.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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