RNASEH2B
Ribonuclease H2 subunit B
Protein Summary
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
- ENST00000336617
- ENSP00000337623
- ENSG00000136104
- ENST00000422660
- ENSP00000389877
- DLEU8
- AGS2
- DLEU8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
transcription factor perturbation | 0.84 | ||
transcription factor binding site profile | 0.78 | ||
biological process | 0.6 | ||
cell line | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.02 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 194 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.02 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 194 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (47)
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | DNA replication | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
DNA replication | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 3 | 3 | 90.9 | |||||
reticulocyte count | 6 | 1 | 6 | 73.9 | |||||
systolic blood pressure | 1 | 1 | 1 | 58.4 | |||||
hematocrit | 2 | 1 | 2 | 56.8 | |||||
mean corpuscular volume | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 90.9 | |||||
reticulocyte count | 6 | 73.9 | |||||
systolic blood pressure | 1 | 58.4 | |||||
hematocrit | 2 | 56.8 | |||||
mean corpuscular volume | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ribonuclease H2 subunit B | VGNC:5101 | 452726 | |||||
Macaque | ribonuclease H2 subunit B | 707995 | ||||||
Mouse | MGI:1914403 | 67153 | ||||||
Rat | RGD:1359710 | 361056 | ||||||
Dog | ribonuclease H2 subunit B | VGNC:45613 | 607281 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ribonuclease H2 subunit B | |||||
Macaque | ribonuclease H2 subunit B | |||||
Mouse | ||||||
Rat | ||||||
Dog | ribonuclease H2 subunit B | |||||
Publication Statistics
PubMed Score 48.02
PubMed score by year
PubTator Score 13.10
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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