RNASEH2B
Ribonuclease H2 subunit B
Protein Summary
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
- ENST00000336617
- ENSP00000337623
- ENSG00000136104
- ENST00000422660
- ENSP00000389877
- DLEU8
- AGS2
- DLEU8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
transcription factor perturbation | 0.84 | ||
transcription factor binding site profile | 0.78 | ||
biological process | 0.6 | ||
cell line | 0.58 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 45.44 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 194 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 45.44 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 194 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 46.8 | |||||
systolic blood pressure | 1 | 1 | 1 | 44.8 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 46.8 | |||||
systolic blood pressure | 1 | 44.8 | |||||
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ribonuclease H2 subunit B | VGNC:5101 | 452726 | |||||
Macaque | ribonuclease H2 subunit B | 707995 | ||||||
Mouse | MGI:1914403 | 67153 | ||||||
Rat | RGD:1359710 | 361056 | ||||||
Dog | ribonuclease H2 subunit B | VGNC:45613 | 607281 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ribonuclease H2 subunit B | |||||
Macaque | ribonuclease H2 subunit B | |||||
Mouse | ||||||
Rat | ||||||
Dog | ribonuclease H2 subunit B | |||||
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (1)
KEGG (1)
Items per page:
1 – 1 of 1
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | DNA replication | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
DNA replication | ||||
Gene Ontology Terms (11)
Functions (1)
Components (3)
Processes (7)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (47)
1 – 10 of 47
RNASEH2C
Family: Enzyme
Novelty: 0.06148299
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
RNASEH2A
Family: Enzyme
Novelty: 0.00478657
Score: 0.999
Data Source: STRINGDB
PCNA
Novelty: 0.03909539
Score: 0.975
Data Source: STRINGDB
SAMHD1
Family: Enzyme
Novelty: 0.00294595
Score: 0.86
Data Source: STRINGDB
AP1M1
Novelty: 0.029282
Score: 0.847
Data Source: STRINGDB
FAM124A
Novelty: 1.51577847
Score: 0.75
Data Source: STRINGDB
TREX1
Family: Enzyme
Novelty: 0.87486677
Score: 0.748
Data Source: STRINGDB
ADAR
Family: Enzyme
Novelty: 0.00135586
Score: 0.684
Data Source: STRINGDB
FEN1
Family: Enzyme
Novelty: 0.00082515
Score: 0.669
Data Source: STRINGDB
RIF1
Novelty: 0.34360368
Score: 0.645
Data Source: STRINGDB
Publication Statistics
PubMed Score 45.44
PubMed score by year
PubTator Score 13.1
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword