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Tdark
CEP162
Centrosomal protein of 162 kDa

Protein Summary
Description
Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257766
  • ENSP00000257766
  • ENSG00000135315
  • ENST00000403245
  • ENSP00000385215
  • ENST00000617909
  • ENSP00000481760

Symbol
  • C6orf84
  • KIAA1009
  • QN1
  • QN1
  • C6orf84
  • KIAA1009
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
histone modification site profile
0.91
transcription factor binding site profile
0.67
cell line
0.62
cellular component
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.61   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.61   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (146)
1 – 10 of 146
SYBU
Tbio
Novelty:  0.06029092
p_int:  0.99999653
p_ni:  0.00000347
Score:  0.193
Data Source:  BioPlex,STRINGDB
CAPN6
Tbio
Novelty:  0.04489237
p_int:  0.999870748
p_ni:  0.000129252
Score:  0.199
Data Source:  BioPlex,STRINGDB
KCTD8
Tbio
Novelty:  0.13877221
p_int:  0.910249981
p_ni:  0.089724153
p_wrong:  0.000025866
Score:  0.68
Data Source:  BioPlex,STRINGDB
CEP290
Tbio
Novelty:  0.00526375
Score:  0.978
Data Source:  STRINGDB
TUBG1
Tbio
Novelty:  0.02252882
Score:  0.969
Data Source:  STRINGDB
CCP110
Tbio
Novelty:  0.02399511
Score:  0.952
Data Source:  STRINGDB
TMEM67
Tbio
Novelty:  0.02573267
Score:  0.951
Data Source:  STRINGDB
CC2D2A
Tbio
Novelty:  0.03684487
Score:  0.95
Data Source:  STRINGDB
AHI1
Tbio
Novelty:  0.01180688
Score:  0.948
Data Source:  STRINGDB
TCTN1
Tbio
Novelty:  0.0657704
Score:  0.947
Data Source:  STRINGDB
Pathways (4)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Gene Ontology Terms (8)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 162
462859
Macaque
centrosomal protein 162
695775
Mouse
MGI:1925343
382090
Rat
RGD:1307365
300880
Dog
centrosomal protein 162
VGNC:39120
474983
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 162
Macaque
centrosomal protein 162
Mouse
Rat
Dog
centrosomal protein 162
Publication Statistics
PubMed Score 32.61
PubMed score by year
PubTator Score 7.75
PubTator score by year