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Tbio
COL13A1
Collagen alpha-1(XIII) chain

Protein Summary
Description
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625). This gene encodes the alpha chain of one of the nonfibrillar collagens. The function of this gene product is not known, however, it has been detected at low levels in all connective tissue-producing cells so it may serve a general function in connective tissues. Unlike most of the collagens, which are secreted into the extracellular matrix, collagen XIII contains a transmembrane domain and the protein has been localized to the plasma membrane. The transcripts for this gene undergo complex and extensive splicing involving at least eight exons. Like other collagens, collagen XIII is a trimer; it is not known whet ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354547
  • ENSP00000346553
  • ENSG00000197467
  • ENST00000357811
  • ENSP00000350463
  • ENST00000398978
  • ENSP00000381949
  • ENST00000517713
  • ENSP00000430061
  • ENST00000520133
  • ENSP00000430173
  • ENST00000520267
  • ENSP00000428057
  • ENST00000522165
  • ENSP00000428342

Symbol
  • CMS19
  • COLXIIIA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
gene perturbation
0.75
transcription factor binding site profile
0.67
cellular component
0.66
disease
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.22   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.22   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0