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Tbio
COL13A1
Collagen alpha-1(XIII) chain

Protein Summary
Description
Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering (PubMed:26626625). This gene encodes the alpha chain of one of the nonfibrillar collagens. The function of this gene product is not known, however, it has been detected at low levels in all connective tissue-producing cells so it may serve a general function in connective tissues. Unlike most of the collagens, which are secreted into the extracellular matrix, collagen XIII contains a transmembrane domain and the protein has been localized to the plasma membrane. The transcripts for this gene undergo complex and extensive splicing involving at least eight exons. Like other collagens, collagen XIII is a trimer; it is not known whet ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354547
  • ENSP00000346553
  • ENSG00000197467
  • ENST00000357811
  • ENSP00000350463
  • ENST00000398978
  • ENSP00000381949
  • ENST00000517713
  • ENSP00000430061
  • ENST00000520133
  • ENSP00000430173
  • ENST00000520267
  • ENSP00000428057
  • ENST00000522165
  • ENSP00000428342

Symbol
  • CMS19
  • COLXIIIA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
gene perturbation
0.75
transcription factor binding site profile
0.67
cellular component
0.66
disease
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
1
1.1
73.6
optic disc size measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
73.6
optic disc size measurement
1
31.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type XIII alpha 1 chain
VGNC:10670
450508
Macaque
collagen type XIII alpha 1 chain
716986
Mouse
MGI:1277201
12817
Rat
RGD:1595704
499431
Dog
collagen type XIII alpha 1 chain
VGNC:39459
609516
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type XIII alpha 1 chain
Macaque
collagen type XIII alpha 1 chain
Mouse
Rat
Dog
collagen type XIII alpha 1 chain
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5TAT6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Reactome
Collagen formation
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Collagen formation
Degradation of the extracellular matrix
Protein-Protein Interactions (78)
1 – 10 of 78
LAIR2
Tbio
Novelty:  0.06117644
p_int:  0.989290423
p_ni:  5e-8
p_wrong:  0.010709527
Data Source:  BioPlex
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
Score:  0.962
Data Source:  STRINGDB
ITGA1
Tbio
Novelty:  0.00545805
Score:  0.939
Data Source:  STRINGDB
COL4A2
Tbio
Novelty:  0.00782053
Score:  0.926
Data Source:  STRINGDB
COL6A1
Tbio
Novelty:  0.00644855
Score:  0.924
Data Source:  STRINGDB
COL8A1
Tbio
Novelty:  0.02203574
Score:  0.924
Data Source:  STRINGDB
COL4A1
Tbio
Novelty:  0.00358049
Score:  0.923
Data Source:  STRINGDB
COL8A2
Tbio
Novelty:  0.01672103
Score:  0.922
Data Source:  STRINGDB
COL9A3
Tbio
Novelty:  0.02556037
Score:  0.922
Data Source:  STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.921
Data Source:  STRINGDB
Publication Statistics
PubMed Score  25.53

PubMed score by year
PubTator Score  11.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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