You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HES5
Transcription factor HES-5

Protein Summary
Description
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity). This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378453
  • ENSP00000367714
  • ENSG00000197921
  • ENST00000612705
  • ENSP00000482150
  • ENSG00000273529

Symbol
  • BHLHB38
  • bHLHb38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease
0.78
molecular function
0.67
PubMedID
0.66
transcription factor
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.46   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.46   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (36)
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
92.1
3
3
0
1.1
92.1
5
4
2
1.1
78.6
5
4
2
1.1
78.6
3
3
0
1.1
68.8
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.1
0
1.1
92.1
2
1.1
78.6
2
1.1
78.6
0
1.1
68.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hes family bHLH transcription factor 5
VGNC:11446
107973860
Mouse
MGI:104876
15208
Rat
RGD:621340
79225
Dog
hes family bHLH transcription factor 5
VGNC:41666
489614
Cow
hes family bHLH transcription factor 5
VGNC:29822
787633
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hes family bHLH transcription factor 5
Mouse
Rat
Dog
hes family bHLH transcription factor 5
Cow
hes family bHLH transcription factor 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5TA89-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
NOTCH1 Intracellular Domain Regulates Transcription
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Disease
Diseases of signal transduction
NOTCH1 Intracellular Domain Regulates Transcription
Gene Ontology Terms (58)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (99)
1 – 10 of 99
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.99
Data Source:  STRINGDB
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
Score:  0.985
Data Source:  STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
Score:  0.981
Data Source:  STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.979
Data Source:  STRINGDB
NOTCH4
Tchem
Novelty:  0.00471643
Score:  0.96
Data Source:  STRINGDB
MAML1
Tbio
Novelty:  0.01302751
Score:  0.954
Data Source:  STRINGDB
MAML2
Tbio
Novelty:  0.00836375
Score:  0.93
Data Source:  STRINGDB
MAML3
Tbio
Novelty:  0.05574812
Score:  0.923
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.917
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.915
Data Source:  STRINGDB
Publication Statistics
PubMed Score  148.46

PubMed score by year
PubTator Score  65.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: