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Tdark
LCE2D
Late cornified envelope protein 2D

Protein Summary
Description
Precursors of the cornified envelope of the stratum corneum.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368784
  • ENSP00000357773
  • ENSG00000187223

Symbol
  • LEP12
  • SPRL1A
  • LEP12
  • SPRL1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.55
metabolite
0.45
tissue sample
0.44
biological term
0.33
cell line
0.32


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.61   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.61   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
LCE2B
Tdark
Novelty:  0.88335558
Score:  0.993
Data Source:  STRINGDB
LCE1B
Tbio
Novelty:  0.06933554
Score:  0.982
Data Source:  STRINGDB
LCE2C
Tdark
Novelty:  4.51851552
Score:  0.981
Data Source:  STRINGDB
LCE6A
Tdark
Novelty:  2.0416597
Score:  0.978
Data Source:  STRINGDB
LCE1D
Tbio
Novelty:  0.52901166
Score:  0.976
Data Source:  STRINGDB
LCE3D
Tbio
Novelty:  0.20614547
Score:  0.974
Data Source:  STRINGDB
LCE3E
Tdark
Novelty:  0.72118892
Score:  0.97
Data Source:  STRINGDB
LCE1A
Tbio
Novelty:  0.04596696
Score:  0.963
Data Source:  STRINGDB
SPRR2G
Tdark
Novelty:  0.7198022
Score:  0.961
Data Source:  STRINGDB
LCE1F
Tdark
Novelty:  1.56312927
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
8
0
1.3
95.5
vitamin D measurement
2
2
2
84.7
2
2
0
1.8
83
1
1
0
1.1
17.6
1
1
0
1.2
12.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
95.5
vitamin D measurement
2
84.7
0
1.8
83
0
1.1
17.6
0
1.2
12.9
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 0.61
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title