Tbio CPTP Ceramide-1-phosphate transfer protein

Protein Summary

Description

Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed:28011644). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996).

Uniprot Accession IDs

• Q5TA50
• Q4G0E6
• Q7L5A4
• CPTP

Gene Name

• CPTP

Ensembl ID

• ENST00000343938
• ENSP00000343890
• ENSG00000224051

Symbol

• GLTPD1
• GLTPD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.76
small molecule perturbation	0.71
molecular function	0.63
tissue sample	0.63
metabolite	0.62

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Ceramide-1-phosphate Transfer Protein

DTO Classes

Protein / Transporter / Ceramide-1-phosphate Transfer Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.53   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 14   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.53   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0