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Tbio
CPTP
Ceramide-1-phosphate transfer protein

Protein Classes
Protein Summary
Description
Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed:28011644). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343938
  • ENSP00000343890
  • ENSG00000224051

Symbol
  • GLTPD1
  • GLTPD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
small molecule perturbation
0.71
molecular function
0.63
tissue sample
0.63
metabolite
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.36   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.36   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ceramide-1-phosphate transfer protein
700679
Mouse
MGI:1933107
79554
Rat
RGD:1359656
313771
Dog
ceramide-1-phosphate transfer protein
VGNC:39583
100855790
Horse
ceramide-1-phosphate transfer protein
VGNC:16843
100061495
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ceramide-1-phosphate transfer protein
Mouse
Rat
Dog
ceramide-1-phosphate transfer protein
Horse
ceramide-1-phosphate transfer protein
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5TA50-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (15)
1 – 10 of 15
ACP4
Tbio
Family: Enzyme
Novelty: 0.01397537
Score: 0.708
Data Source: STRINGDB
CERK
Tchem
Family: Kinase
Novelty: 0.0103948
Score: 0.643
Data Source: STRINGDB
GLTP
Tbio
Novelty: 0.01044466
Score: 0.619
Data Source: STRINGDB
ACER1
Tbio
Family: Enzyme
Novelty: 0.05571844
Score: 0.547
Data Source: STRINGDB
CKAP4
Tbio
Novelty: 0.02104039
Score: 0.494
Data Source: STRINGDB
DFFB
Tbio
Novelty: 0.00475349
Score: 0.475
Data Source: STRINGDB
METTL27
Tdark
Novelty: 0.34658724
Score: 0.464
Data Source: STRINGDB
PIK3IP1
Tbio
Family: Enzyme
Novelty: 0.07364653
Score: 0.459
Data Source: STRINGDB
RERE
Tbio
Family: TF
Novelty: 0.03065098
Score: 0.458
Data Source: STRINGDB
RNF225
Tdark
Score: 0.453
Data Source: STRINGDB
Publication Statistics
PubMed Score  44.36

PubMed score by year
PubTator Score  13.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer