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Tbio
INTS11
Integrator complex subunit 11

Protein Summary
Description
Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419704
  • ENSP00000404886
  • ENSG00000127054
  • ENST00000435064
  • ENSP00000413493
  • ENST00000450926
  • ENSP00000392848
  • ENST00000540437
  • ENSP00000445001
  • ENST00000545578
  • ENSP00000444672

Symbol
  • CPSF3L
  • RC68
  • RC68
  • INT11
  • RC-68
  • CPSF3L
  • CPSF73L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.38   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.38   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (119)
TRIP13
Tbio
Family:  Enzyme
Novelty:  0.00660506
p_int:  0.889643711
p_ni:  0.110356289
Score:  0.551
Data Source:  BioPlex,STRINGDB
NABP2
Tbio
Novelty:  0.09046897
p_int:  0.793906539
p_ni:  0.206093425
p_wrong:  3.6e-8
Score:  0.941
Data Source:  BioPlex,STRINGDB
INTS9
Tbio
Novelty:  0.06037786
Score:  0.999
Data Source:  STRINGDB
INTS1
Tbio
Novelty:  0.17523407
Score:  0.999
Data Source:  STRINGDB
INTS6
Tbio
Novelty:  0.02680242
Score:  0.999
Data Source:  STRINGDB
INTS3
Tbio
Novelty:  0.13398603
Score:  0.999
Data Source:  STRINGDB
INTS5
Tbio
Novelty:  0.02127142
Score:  0.999
Data Source:  STRINGDB
INTS4
Tbio
Novelty:  0.20868831
Score:  0.998
Data Source:  STRINGDB
INTS12
Tbio
Family:  Epigenetic
Novelty:  0.09023473
Score:  0.99
Data Source:  STRINGDB
INTS10
Tbio
Novelty:  0.15415606
Score:  0.989
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
67.9
intraocular pressure measurement
1
2
2
60.2
1
1
0
1.1
44.6
Drugs affecting bone structure and mineralization use measurement
1
1
1
11.4
corneal resistance factor
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
67.9
intraocular pressure measurement
2
60.2
0
1.1
44.6
Drugs affecting bone structure and mineralization use measurement
1
11.4
corneal resistance factor
1
11.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
integrator complex subunit 11
700176
Mouse
MGI:1919207
71957
Rat
RGD:1306841
298688
Dog
integrator complex subunit 11
VGNC:42047
100855777
Horse
integrator complex subunit 11
VGNC:19087
100065939
Species
Name
OMA
EggNOG
Inparanoid
Macaque
integrator complex subunit 11
Mouse
Rat
Dog
integrator complex subunit 11
Horse
integrator complex subunit 11
Publication Statistics
PubMed Score 55.38
PubMed score by year
PubTator Score 6.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title