Tbio INTS11 Integrator complex subunit 11

Protein Summary

Description

Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q5TA45
• A8K5S2
• B3KPR3
• B4DM87
• G3V1S5
• Q5TA46
• Q5TA48
• Q5TA52
• Q5TA53
• Q5TA54
• Q7L3D7
• Q96HY1
• Q9BW36
• Q9H0F9
• Q9H8R5
• Q9HAA6
• Q9NWX9
• Int11

Gene Name

• INTS11

Ensembl ID

• ENST00000419704
• ENSP00000404886
• ENSG00000127054
• ENST00000435064
• ENSP00000413493
• ENST00000450926
• ENSP00000392848
• ENST00000540437
• ENSP00000445001
• ENST00000545578
• ENSP00000444672

Symbol

• CPSF3L
• RC68
• RC68
• INT11
• RC-68
• CPSF3L
• CPSF73L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endoribonuclease / Integrator Complex Subunit 11

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Polyadenylation Factor / Integrator Complex Subunit 11

Protein / Nucleic Acid Binding / Rna Binding Protein / Endoribonuclease / Integrator Complex Subunit 11

DTO Classes

Protein / Enzyme / Nuclease / Endoribonuclease / Integrator Complex Subunit 11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.38   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.38   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0